2-Amino-4-chlorobenzonitrile

Synonym(s):4-Chloroanthranilonitrile;5-Chloro-2-cyanoaniline

CAS NO.：38487-86-4
Empirical Formula: C7H5ClN2
Molecular Weight: 152.58
MDL number: MFCD00035927
EINECS: 253-967-8
SAFETY DATA SHEET (SDS)
Update Date: 2024-10-29 18:21:28

What is 2-Amino-4-chlorobenzonitrile?

The Uses of 2-Amino-4-chlorobenzonitrile

2-Amino-4-chlorobenzonitrile may be used in the preparation of the following:

6-chloro-4-(1-diethylamino-4-pentylamino)-2-(p-methoxyphenyl)-quinazoline dihydrochloride
7-chloro-4-(1-diethylamino-4-pentylamino)-2-(p-methoxyphenyl)-quinazoline dihydrochloride
4,7-dichloro-2-(2-methylprop-1-enyl)-6-nitroquinazoline
6-chlorotacrine
N-(2-chloro-5-cyanophenyl)-4,4,4-trifluorobutanamide

General Description

2-Amino-4-chlorobenzonitrile (2A4CBN) is a benzonitrile derivative. A study of the molecular structure, vibrational spectra and NBO analysis of 2A4CBN has been undertaken. Transformation of 2A4CBN into quinazoline-2,4(1H,3H)-diones at atmospheric pressure of CO₂in the presence of monomeric tungstate, TBA₂[WO₄] (TBA = tetra-n-butylammonium) has been reported.

Properties of 2-Amino-4-chlorobenzonitrile

Melting point:	157-162 °C(lit.)
Boiling point:	305.8±27.0 °C(Predicted)
Density	1.33±0.1 g/cm3(Predicted)
form	powder to crystal
pka	0.76±0.10(Predicted)
color	Light orange to Yellow to Green
BRN	2085559
CAS DataBase Reference	38487-86-4(CAS DataBase Reference)
EPA Substance Registry System	Benzonitrile, 2-amino-4-chloro- (38487-86-4)

Safety information for 2-Amino-4-chlorobenzonitrile

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.