2-Amino-3,4-dimethyl-3H-imidazo[4,5-f]quinoline
- CAS NO.:77094-11-2
- Empirical Formula: C12H12N4
- Molecular Weight: 212.25
- MDL number: MFCD00468067
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-05-18 11:31:16
What is 2-Amino-3,4-dimethyl-3H-imidazo[4,5-f]quinoline?
Chemical properties
Yellow Crystalline Solid
The Uses of 2-Amino-3,4-dimethyl-3H-imidazo[4,5-f]quinoline
Mutagenic heterocyclic amines in cooked food
What are the applications of Application
2-Amino-3,4-dimethyl-3H-imidazo[4,5-f]quinoline is a mutagenic heterocyclic amine found in cooked food.
Production Methods
Heterocyclic amines are formed by condensation of creatinine with amino acids during heating or cooking of meat (beef, pork, chicken, and fish). They have also been detected in processed food flavorings, beer, wine, and cigarette smoke. 2-Amino-3,4-dimethylimidazo[4,5-f]quinoline (MeIQ) and related heterocyclic amines are produced in small quantities for research purposes. Exposure to MeIQ and related heterocyclic amines occurs primarily through the consumption of cooked meats.Concentrations of heterocyclic amines in meats varied under different cooking conditions (375). The highest concentrations of MeIQ were detected in grilled fish, which appear to be the major dietary source of heterocyclic amines in Japanese. U.S. surveys of dietary intakes of heterocyclic amines in cooked foods have also been reported. Occupational exposure to heterocyclic amines may occur by inhalation of aerosolized particles formed during the cooking process.
Definition
ChEBI: MeIQ is an aminoquinoline.
General Description
Pale orange crystalline solid or light yellow powder.
Air & Water Reactions
2-AMINO-3,4-DIMETHYL-3H-IMIDAZO [4,5-F]QUINOLINE is sensitive to light and air. Slightly water soluble .
Reactivity Profile
2-AMINO-3,4-DIMETHYL-3H-IMIDAZO [4,5-F]QUINOLINE is rapidly degraded by dilute hypochlorite.
Health Hazard
ACUTE/CHRONIC HAZARDS: 2-AMINO-3,4-DIMETHYL-3H-IMIDAZO [4,5-F]QUINOLINE may emit potentially toxic fumes when involved in a fire.
Fire Hazard
Flash point data for 2-AMINO-3,4-DIMETHYL-3H-IMIDAZO [4,5-F]QUINOLINE are not available; however, 2-AMINO-3,4-DIMETHYL-3H-IMIDAZO [4,5-F]QUINOLINE is probably combustible.
Safety Profile
Confirmed carcinogen with experimental carcinogenic data. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx,.
Carcinogenicity
MeIQ is reasonably anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in experimental animals and supporting genotoxicity data.
Properties of 2-Amino-3,4-dimethyl-3H-imidazo[4,5-f]quinoline
Melting point: | 291-293 |
Boiling point: | 342.09°C (rough estimate) |
Density | 1.2046 (rough estimate) |
refractive index | 1.5000 (estimate) |
storage temp. | Refrigerator |
solubility | Methanol (Slightly) |
pka | 6.22±0.40(Predicted) |
form | Solid |
color | Yellow |
Stability: | Hygroscopic |
IARC | 2B (Vol. Sup 7, 56) 1993 |
EPA Substance Registry System | 2-Amino-3,4-dimethylimidazo(4,5-f)quinoline (77094-11-2) |
Safety information for 2-Amino-3,4-dimethyl-3H-imidazo[4,5-f]quinoline
Signal word | Warning |
Pictogram(s) |
Health Hazard GHS08 |
GHS Hazard Statements |
H341:Germ cell mutagenicity H351:Carcinogenicity |
Precautionary Statement Codes |
P201:Obtain special instructions before use. P202:Do not handle until all safety precautions have been read and understood. P280:Wear protective gloves/protective clothing/eye protection/face protection. P308+P313:IF exposed or concerned: Get medical advice/attention. P405:Store locked up. P501:Dispose of contents/container to..… |
Computed Descriptors for 2-Amino-3,4-dimethyl-3H-imidazo[4,5-f]quinoline
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