2-amino-1-(4-chlorobenzyl)-5-trifluoromethylbenzimidazole

CAS NO.：150493-34-8
Empirical Formula: C15H11ClF3N3
Molecular Weight: 325.72
SAFETY DATA SHEET (SDS)
Update Date: 2024-07-02 08:54:59

What is 2-amino-1-(4-chlorobenzyl)-5-trifluoromethylbenzimidazole?

Biological Activity

NS-638 is a non-peptidic small molecule with Ca2+-ion channel blocking properties. The IC50 value for intracellular blocking of the increase in Ca2+ concentration activated by K+ was 3.4 μM.

in vivo

In the mouse middle cerebral artery occlusion model, NS-638 administered ip (50 mg kg-1) at 1 h and 6 h post-ischemia, and once a day for the next two days, results in a 48% reduction in total infarct volume. It does not show protection against ischemic neuronal damage in the gerbil model of bilateral carotid artery occlusion.

Properties of 2-amino-1-(4-chlorobenzyl)-5-trifluoromethylbenzimidazole

Boiling point:	476.3±55.0 °C(Predicted)
Density	1.45±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMF: 5 mg/ml; DMSO: 5 mg/ml; Ethanol: 2 mg/ml; PBS (pH 7.2): insol
form	A solid
pka	5.15±0.10(Predicted)
color	White to off-white

Safety information for 2-amino-1-(4-chlorobenzyl)-5-trifluoromethylbenzimidazole

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.