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HomeProduct name list2-Acetylphenothiazine

2-Acetylphenothiazine

Synonym(s):NADPH Oxidase-1 Inhibitor, ML171, 2-APT, 2-acetylphenothiazine;NOX1 Inhibitor, ML171 - CAS 6631-94-3 - Calbiochem

  • CAS NO.:6631-94-3
  • Empirical Formula: C14H11NOS
  • Molecular Weight: 241.31
  • MDL number: MFCD00005017
  • EINECS: 229-626-4
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2023-06-08 09:02:34
2-Acetylphenothiazine  Structural

What is 2-Acetylphenothiazine ?

Description

2-Acetylphenothiazine (2-APT) is a selective, cell-active inhibitor of NADPH oxidase 1 (NOX1) that blocks the generation of reactive oxygen species (ROS) in HT-29 cells with an IC50 value of 0.129 μM. It does not affect xanthine oxidase-dependent or mitochondrial ROS generation. 2-APT prevents ROS-dependent formation of ECM-degrading invadopodia in colon cancer cells. It also abolishes collagen-induced superoxide production by platelets (IC50 = 306 nM), preventing platelet aggregation and thrombus formation. 2-APT protects beta cells from cytokine-induced apoptosis by inhibiting NOX1. 2-APT can also activate the human transient receptor potential ankyrin 1 (TRPA1) nociceptor at 1-30 μM.

Chemical properties

Yellow white or green crystalline powder

The Uses of 2-Acetylphenothiazine

2-Acetylphenothiazine is a potent and selective NADPH oxidase 1 (NOX1) inhibitor that blocks NOX1-dependent ROS generation. 2-Acetylphenothiazine has been shown to inhibit SrcYF-induced invadopodia formation in human DLD1 colon cancer cells.

The Uses of 2-Acetylphenothiazine

2-Acetylphenothiazine was used as a NADPH oxidase (NOX) inhibitor in human platelet functional responses and intracellular signaling pathways. It was also used in the synthesis of 2-phenothiazin-2′-yl-cinchoninic acid derivatives.

What are the applications of Application

2-Acetylphenothiazine is A biochemical that was used as a Nox (NADPH oxidase) inhibitor in human platelet functional responses and intracellular signaling pathways.

Definition

ChEBI: 1-(10H-phenothiazin-2-yl)ethanone is a member of phenothiazines.

Properties of 2-Acetylphenothiazine

Melting point: 180-185 °C (lit.)
Boiling point: 455.7±34.0 °C(Predicted)
Density  1.249±0.06 g/cm3(Predicted)
storage temp.  Sealed in dry,2-8°C
solubility  DMSO (Slightly), Methanol (Slightly, Heated)
form  Dark yellow-orange powder
pka -2.45±0.20(Predicted)
color  Yellow to Dark Orange
λmax 244nm(MeOH)(lit.)
CAS DataBase Reference 6631-94-3(CAS DataBase Reference)

Safety information for 2-Acetylphenothiazine

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral
H412:Hazardous to the aquatic environment, long-term hazard
Precautionary Statement Codes P273:Avoid release to the environment.

Computed Descriptors for 2-Acetylphenothiazine

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