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HomeProduct name list2-(2-FUROYL)-LEU-ILE-GLY-ARG-LEU-ORN-NH2

2-(2-FUROYL)-LEU-ILE-GLY-ARG-LEU-ORN-NH2

Synonym(s):2-fAP;2fLI;2-f-LIGRLO-NH2;2-Fly;2-Furoyl-Leu-Ile-Gly-Arg-Leu-Orn-NH2 trifluoroacetate salt

2-(2-FUROYL)-LEU-ILE-GLY-ARG-LEU-ORN-NH2 Structural

What is 2-(2-FUROYL)-LEU-ILE-GLY-ARG-LEU-ORN-NH2?

The Uses of 2-(2-FUROYL)-LEU-ILE-GLY-ARG-LEU-ORN-NH2

2-Furoyl-LIGRLO-amide trifluoroacetate salt may be used as a protease-activated receptor 2 (PAR2) agonist in endothelial progenitor cells (EPCs) and in transient receptor potential cation channel subfamily V member (TRPV4)-transfected HEK293t cells.

What are the applications of Application

2-Furoyl-LIGRLO-amide trifluoroacetate salt is a potent, selective PAR2 agonist

General Description

2-Furoyl-LIGRLO-amide trifluoroacetate salt is a peptide that acts as a proteinase-activated receptor-2 (PAR2) agonist, and contains a furoyl group addition at its N-terminal.

Biological Activity

potent and selective par2 receptor agonist (pd2 = 7.0). causes a dose-dependent relaxation of murine femoral arteries.

Biochem/physiol Actions

2-Furoyl-LIGRLO-amide is a potent and selective protease-activated receptor 2 (PAR2) agonist. PAR-2 activation is associated with increases in cAMP and intracellular Ca(2+). Immunoblot analysis revealed increases in phosphorylation of epidermal growth factor (EGF) receptor (EGFR) tyrosine kinase, Src, Pyk2, cRaf, and ERK1/2 in response to PAR-2 activation. 2-Furoyl-LIGRLO-amide is nearly 100-fold more potent than SLIGRL-NH2 (Cat. No. S9317). 2-Furoyl-LIGRLO-amide caused both an endothelium-dependent relaxation and an endothelium-independent contraction. It produced delayed (6 hours later) facilitation of capsaicin-evoked visceral nociception, an effect being much more potent than SLIGRL-NH2. Such effects were mimicked by i.col. trypsin. 2-f-LIGRL-NH2, coadministered repeatedly with caerulein six times in total, abolished the caerulein-evoked abdominal hyperalgesia/allodynia in WT, but not PAR2-KO, mice. Repeated doses of 2-f-LIGRL-NH2 moderately attenuated the severity of caerulein-induced pancreatitis in WT animals. It induced a similar dose-dependent increase in Ca2 levels in the presence and absence of b-arrestins.

storage

Store at -20°C

Properties of 2-(2-FUROYL)-LEU-ILE-GLY-ARG-LEU-ORN-NH2

Density  1.33±0.1 g/cm3(Predicted)
storage temp.  -20°C
solubility  Soluble in H2O
pka 12.91±0.46(Predicted)
form  powder
color  white
Water Solubility  Soluble to 1 mg/ml in water

Safety information for 2-(2-FUROYL)-LEU-ILE-GLY-ARG-LEU-ORN-NH2

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P264:Wash hands thoroughly after handling.
P264:Wash skin thouroughly after handling.
P271:Use only outdoors or in a well-ventilated area.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352:IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for 2-(2-FUROYL)-LEU-ILE-GLY-ARG-LEU-ORN-NH2

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