2-(1,3,2-DIOXABOROLAN-2-YL)BENZONITRILE

Synonym(s):2-(1,3,2-Dioxaborolan-2-yl)benzonitrile;2-Cyanophenylboronic acid propanediol ester

CAS NO.：172732-52-4
Empirical Formula: C10H10BNO2
Molecular Weight: 187
MDL number: MFCD04039012
SAFETY DATA SHEET (SDS)
Update Date: 2024-04-08 16:27:35

2-(1,3,2-DIOXABOROLAN-2-YL)BENZONITRILE Structural

What is 2-(1,3,2-DIOXABOROLAN-2-YL)BENZONITRILE?

Chemical properties

White powder

The Uses of 2-(1,3,2-DIOXABOROLAN-2-YL)BENZONITRILE

2-(2-Cyanophenyl)-1,3,2-dioxaborinane is used in the synthesis of AMPA receptor antagonists in the treatment of neurological diseases causing dysfunction of glutamatergic neurotransmission. Also used in the small scale synthesis of Perampanel (P285520), an AMPA receptor antagonist.

Properties of 2-(1,3,2-DIOXABOROLAN-2-YL)BENZONITRILE

Melting point:	46-56 °C(lit.)
Boiling point:	372.4±25.0 °C(Predicted)
Density	1.13±0.1 g/cm3(Predicted)
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
solubility	Chloroform (Slightly), Methanol (Slightly)
form	solid
color	white
Stability:	Hygroscopic

Safety information for 2-(1,3,2-DIOXABOROLAN-2-YL)BENZONITRILE

Signal word	Warning
Pictogram(s)	Skull and Crossbones Acute Toxicity GHS06
GHS Hazard Statements	H301:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up.