(1S,2R)-(-)-cis-1-Amino-2-indanol
Synonym(s):(1S,2R)-(−)-cis-1-Amino-2-hydroxyindane
- CAS NO.：126456-43-7
- Empirical Formula: C9H11NO
- Molecular Weight: 149.19
- MDL number: MFCD00216655
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-07 13:31:19
What is (1S,2R)-(-)-cis-1-Amino-2-indanol?
Chemical properties
white to light yellow crystal powder
The Uses of (1S,2R)-(-)-cis-1-Amino-2-indanol
(1S,2R)-(-)-cis-1-Amino-2-indanol is used as a reagent in the synthesis of heterocyclic compounds as integrase inhibiting antiviral agents. It is also a key intermediate of the HIV protease inhibitor, Indinavir (I525000).
The Uses of (1S,2R)-(-)-cis-1-Amino-2-indanol
1S,2R)-(-)-cis-1-Amino-2-indanol may be used to prepare:
- (-)-1,2,5,6-Tetrahydropyridine by reacting with methyl (E,E)-4-oxo-2-[(2,6,6-trimethylcyclohex-1-enyl)vinyl}but-2-enoate.
- Oxazaborolidine catalysts, which can catalyze the asymmetric reduction of aromatic ketones with high enantioselectivity.
- (RS,1S,2R)-(-)-2,4,6-Trimethylbenzenesulfinic acid 1-(2,4,6-trimethylbenzenesulfonylamino)indan-2-yl ester.
What are the applications of Application
(1S,2R)-1-Amino-indan-2-ol is a chiral ligand for asymmetric synthesis
General Description
(1S,2R)-(-)-cis-1-Amino-2-indanol is a main constituent of indinavir, a potent HIV (human immunodeficiency virus) protease inhibitor.
Properties of (1S,2R)-(-)-cis-1-Amino-2-indanol
| Melting point: | 118-121 °C(lit.) |
| Boiling point: | 270.27°C (rough estimate) |
| alpha | -62 º (c=0.5, CHCl3) |
| Density | 1.0753 (rough estimate) |
| RTECS | NK7525500 |
| refractive index | 1.5760 (estimate) |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| solubility | soluble in Methanol |
| form | Powder |
| pka | 14.79±0.40(Predicted) |
| color | White to light beige |
| optical activity | [α]20/D 61°, c = 0.5 in chloroform |
| Water Solubility | slightly soluble |
| Sensitive | Air Sensitive |
| BRN | 4292559 |
| CAS DataBase Reference | 126456-43-7(CAS DataBase Reference) |
Safety information for (1S,2R)-(-)-cis-1-Amino-2-indanol
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for (1S,2R)-(-)-cis-1-Amino-2-indanol
| InChIKey | LOPKSXMQWBYUOI-BDAKNGLRSA-N |
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