(1S,2R)-(-)-cis-1-Amino-2-indanol
Synonym(s):(1S,2R)-(−)-cis-1-Amino-2-hydroxyindane
- CAS NO.：126456-43-7
- Empirical Formula: C9H11NO
- Molecular Weight: 149.19
- MDL number: MFCD00216655
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-04-29 14:28:21
What is (1S,2R)-(-)-cis-1-Amino-2-indanol?
Chemical properties
white to light yellow crystal powder
The Uses of (1S,2R)-(-)-cis-1-Amino-2-indanol
(1S,2R)-(-)-cis-1-Amino-2-indanol is used as a reagent in the synthesis of heterocyclic compounds as integrase inhibiting antiviral agents. It is also a key intermediate of the HIV protease inhibitor, Indinavir (I525000).
The Uses of (1S,2R)-(-)-cis-1-Amino-2-indanol
1S,2R)-(-)-cis-1-Amino-2-indanol may be used to prepare:
- (-)-1,2,5,6-Tetrahydropyridine by reacting with methyl (E,E)-4-oxo-2-[(2,6,6-trimethylcyclohex-1-enyl)vinyl}but-2-enoate.
- Oxazaborolidine catalysts, which can catalyze the asymmetric reduction of aromatic ketones with high enantioselectivity.
- (RS,1S,2R)-(-)-2,4,6-Trimethylbenzenesulfinic acid 1-(2,4,6-trimethylbenzenesulfonylamino)indan-2-yl ester.
What are the applications of Application
(1S,2R)-1-Amino-indan-2-ol is a chiral ligand for asymmetric synthesis
General Description
(1S,2R)-(-)-cis-1-Amino-2-indanol is a main constituent of indinavir, a potent HIV (human immunodeficiency virus) protease inhibitor.
Properties of (1S,2R)-(-)-cis-1-Amino-2-indanol
| Melting point: | 118-121 °C(lit.) |
| Boiling point: | 270.27°C (rough estimate) |
| alpha | -62 º (c=0.5, CHCl3) |
| Density | 1.0753 (rough estimate) |
| RTECS | NK7525500 |
| refractive index | 1.5760 (estimate) |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| solubility | soluble in Methanol |
| form | Powder |
| pka | 14.79±0.40(Predicted) |
| color | White to light beige |
| optical activity | [α]20/D 61°, c = 0.5 in chloroform |
| Water Solubility | slightly soluble |
| Sensitive | Air Sensitive |
| BRN | 4292559 |
| CAS DataBase Reference | 126456-43-7(CAS DataBase Reference) |
Safety information for (1S,2R)-(-)-cis-1-Amino-2-indanol
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for (1S,2R)-(-)-cis-1-Amino-2-indanol
| InChIKey | LOPKSXMQWBYUOI-BDAKNGLRSA-N |
New Products
6-Bromo 2-Iodo Indole Pyridine 2,4,6-Tricarboxaldehyde Fosfomycin EP impurity D Ivermectin EP Impurity B Rimegepant Impurity 3 Tubulysin D Tubulysin C Tubulysin H Tubulysin A 2-[2-[3(S)-3[2-(7-chloro-2-quinolinyl) ethenyl] phenyl-3- hydroxyl propyl] phenyl]-2-propanol 2-(1-(Mercaptomethyl) cyclopropyl) acetonitrile 2-[[(3aR,4S,6R,6aS)-6-Aminotetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]ethanol ethanedioate Calcium Sodium Phosphosilicate IH Imeglimin Hydrochloride IH Fuel shell Benzene butanoic acid, 2-hydroxy-3-iodo-, methyl ester 4-(Azidomethyl)-3-chloropyridine Methyl 4-amino-3-(pyrrolidin-1-yl)benzoate 2-Chloro-3-(chloromethyl)pyridine Methyl 4-amino-3-(dihexylamino)benzoate 3,6-Bis(4-iodophenyl)-2,5-dihydropyrrolo[3,4-c]pyrrole-1,4-dione 2-(Tert-butoxycarbonyl)-5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxylic acid 6-Bromo-2-methoxy-3-(4-methyl-1H-imidazol-1-yl)pyridine (1S)-1,5-Anhydro-1-C-[4-chloro-3-[[4-[[(3S)-tetrahydro-3-furanyl]oxy]phenyl]methyl]phenyl]-D-glucitoRelated products of tetrahydrofuran
![N-[N,O-ISOPROPYLIDENE-(2R)-HYDROXY INDAN-(1S)-YL]-(2R)-BENZYL-(4S,5)-EPOXY PENTANAMIDE](https://img.chemicalbook.in/CAS/GIF/158512-24-4.gif)
![[1(1S,2R),5(S)]-2,3,5-Trideoxy-N-(2,3-dihydro-2-hydroxy-1H-inden-1-yl)-5-[2-[[(1,1-dimethylethyl)amino]carbonyl]-1-piperazinyl]-2-(phenylmethyl)-D-erythro-pentonamide](https://img.chemicalbook.in/CAS/GIF/150323-38-9.gif)
You may like
-
(1S,2R)-(-)-1-Amino-2-indanol CAS 126456-43-7View Details
126456-43-7 -
(1S,2R)-(−)-cis-1-Amino-2-indanol CAS 126456-43-7View Details
126456-43-7 -
![3,6-Bis(4-iodophenyl)-2,5-dihydropyrrolo[3,4-c]pyrrole-1,4-dione](https://img.chemicalbook.in//ProductImageIndia/2024-09/Raw/54575d9a-6e8e-412f-ab6d-3557d5ed92e3.jpg)
3,6-Bis(4-iodophenyl)-2,5-dihydropyrrolo[3,4-c]pyrrole-1,4-dioneView Details
952145-70-9 -
Sidchem 730View Details -
Sidchem BT 20View Details -
1572177-89-9View Details
1572177-89-9 -
6390-09-6View Details
6390-09-6 -
6-Bromo indoleView Details
Statement: All products displayed on this website are only used for non medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.