19-HYDROXY-4-ANDROSTENE-3,17-DIONE
Synonym(s):4-Androsten-19-ol-3,17-dione;4-Androstene-3,17-dione-19-ol
- CAS NO.：510-64-5
- Empirical Formula: C19H26O3
- Molecular Weight: 302.41
- MDL number: MFCD00003616
- EINECS: 208-116-5
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-03-21 13:23:50
What is 19-HYDROXY-4-ANDROSTENE-3,17-DIONE?
Chemical properties
Off-White Solid
The Uses of 19-HYDROXY-4-ANDROSTENE-3,17-DIONE
A novel substituted estrogen as aromatase inhibitor
The Uses of 19-HYDROXY-4-ANDROSTENE-3,17-DIONE
19-Hydroxyandrostendione is a novel substituted estrogen as aromatase inhibitor. It induces neuroendocrine trans-differentiation of prostate cancer cells via an ectopic olactory receptor.
Definition
ChEBI: 19-hydroxyandrost-4-ene-3,17-dione is a 19-hydroxy steroid, a 3-oxo steroid, a 17-oxo steroid and an androstanoid. It has a role as a mouse metabolite.
Purification Methods
Recrystallise 19-hydroxy-4-androsten-3,17-dione from Me2CO/hexane or Et2O/hexane. It has UV with max at 242nm in EtOH or MeOH. The 19-acetoxy derivative has [] 26D +185o (CHCl3) and max 237.5nm in EtOH. [Ehrenstein & Dünnenberger J Org Chem 21 774 1956, Beilstein 8 IV2162.]
Properties of 19-HYDROXY-4-ANDROSTENE-3,17-DIONE
| Melting point: | 168-169 °C(lit.) |
| Boiling point: | 485.4±45.0 °C(Predicted) |
| Density | 1.19±0.1 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Store in freezer, under -20°C |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 14.90±0.10(Predicted) |
| color | Off-White to Pale Yellow |
| optical activity | [α]/D +190±5°, c = 1 in chloroform |
| BRN | 2567249 |
| CAS DataBase Reference | 510-64-5(CAS DataBase Reference) |
| NIST Chemistry Reference | 19-Hydroxyandrost-4-ene-3,17-dione(510-64-5) |
Safety information for 19-HYDROXY-4-ANDROSTENE-3,17-DIONE
| Signal word | Warning |
| Pictogram(s) |
 Health Hazard GHS08 |
| GHS Hazard Statements |
H361:Reproductive toxicity |
| Precautionary Statement Codes |
P281:Use personal protective equipment as required. |
Computed Descriptors for 19-HYDROXY-4-ANDROSTENE-3,17-DIONE
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