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HomeProduct name list18alpha-Glycyrrhetinic acid

18alpha-Glycyrrhetinic acid

  • CAS NO.:1449-05-4
  • Empirical Formula: C30H46O4
  • Molecular Weight: 470.68
  • MDL number: MFCD00064897
  • EINECS: 215-907-9
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-20 11:41:24
18alpha-Glycyrrhetinic acid Structural

What is 18alpha-Glycyrrhetinic acid?

The Uses of 18alpha-Glycyrrhetinic acid

18α-Glycyrrhetinic acid may be used to synthesize:

  • 3-keto-18α-glycyrrhetinic acid
  • methyl esters of 18α-glycyrrhetinic acid
  • methyl esters of 3-keto-18α-glycyrrhetinic acid

What are the applications of Application

18α-Glycyrrhetinic acid is the aglycone of glycyrrhizin

General Description

18α-Glycyrrhetinic acid (18α-GA) is a bioactive triterpenoid found in licorice. It shows selective inhibition of 11-HSD1 (11-hydroxysteroid dehydrogenase 1). It also shows anti-proliferative and apoptotic effect on hepatic stellate cells (HSCs).

Properties of 18alpha-Glycyrrhetinic acid

Melting point: 331-333°C
Boiling point: 492.11°C (rough estimate)
Density  0.9967 (rough estimate)
refractive index  1.4800 (estimate)
storage temp.  2-8°C
solubility  DMSO (Slightly), Methanol (Slightly)
pka 4.71±0.70(Predicted)
form  Solid
color  White to Off-White
CAS DataBase Reference 1449-05-4(CAS DataBase Reference)

Safety information for 18alpha-Glycyrrhetinic acid

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral

Computed Descriptors for 18alpha-Glycyrrhetinic acid

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