1,8-Naphthyridine
- CAS NO.:254-60-4
- Empirical Formula: C8H6N2
- Molecular Weight: 130.15
- MDL number: MFCD00059751
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-06-08 17:06:37
What is 1,8-Naphthyridine?
Description
1,8-Naphthyridine is an organic compound with the formula C8H6N2. It is the most well-studied of the six isomeric naphthyridines, a subset of diazanaphthalenes with nitrogen in the separate rings. Enoxacin, nalidixic acid, and trovafloxacin are 1,8-naphthyridine derivatives with antibacterial properties related to the fluoroquinolones.
The Uses of 1,8-Naphthyridine
1,8-naphthyridine (napy) and its simplest 2-methyl and 2,7-dimethyl derivatives may act as monodentate and bidentate ligands, resembling the behavior of the carboxylate ligands.
Definition
ChEBI: 1,8-naphthyridine is a naphthyridine in which the nitrogens are situated at positions 1 and 8.
Purification Methods
Purify 1,8-naphthyridine through an Al2O3 column and elute with toluene and pet ether, evaporate the eluate, crystallise the residue from pet ether (b 60-80o), and sublime it at 80o/13mm. The picrate [15936-16-0] has m 207-208o (from EtOH), and the methiodide has m 180-181o (from EtOH). [Hawes & Wibberley J Chem Soc (C) 1564 1967, UV: Armarego Physical Methods in Heterocyclic Chemistry (Ed Katritzky, Academic Press) Vol III 134 1971, Beilstein 23 II 178, 23 III/IV 1237.]
Properties of 1,8-Naphthyridine
Melting point: | 99.8-99.9°C |
Boiling point: | 248.9±13.0 °C(Predicted) |
Density | 1.183±0.06 g/cm3(Predicted) |
storage temp. | Sealed in dry,Room Temperature |
form | powder to crystal |
pka | 3.55±0.10(Predicted) |
pka | 3.39 |
color | White to Light yellow to Light orange |
CAS DataBase Reference | 254-60-4(CAS DataBase Reference) |
Safety information for 1,8-Naphthyridine
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 1,8-Naphthyridine
InChIKey | FLBAYUMRQUHISI-UHFFFAOYSA-N |
New Products
Tert-butyl bis(2-chloroethyl)carbamate (S)-3-Aminobutanenitrile hydrochloride N-Boc-D-alaninol N-BOC-D/L-ALANINOL 3-(2,4-Dimethoxybenzyl)dihydropyrimidine-2,4(1H,3H)-dione 6-Bromo-3-iodo-1-methyl-1H-indazole 7-Bromo-1H-indazole 3-Morpholino-1-(4-nitrophenyl)-5,6-dihydropyridin- 2(1H)-one Tropic acid N-octanoyl benzotriazole Electrolytic Iron Powder 1,1’-CARBONYLDIIMIDAZOLE R-2-BENZYLOXY PROPIONIC ACID 1,1’-CARBONYLDI (1,2-4 TRIAZOLE) 4-HYDROXY BENZYL ALCOHOL S-2-CHLORO PROPIONIC ACID (2-Hydroxyphenyl)acetonitrile 4-Bromopyrazole 5-BROMO-2CYANO PYRIDINE 5,6-Dimethoxyindanone 5-broMo-2-chloro-N-cyclopentylpyriMidin-4-aMine 4-Ethylbenzylamine N-(5-Amino-2-methylphenyl)acetamide Methyl 5-bromo-2-chloro-3-nitrobenzoateRelated products of tetrahydrofuran
You may like
-
1,8-Naphthyridine CAS 254-60-4View Details
254-60-4 -
1,8-Naphthyridine CAS 254-60-4View Details
254-60-4 -
Ste-Glu-AEEA-AEEA-OSUView Details
1169630-40-3 -
1446013-08-6 Fmoc-His-Aib-OH TFA 98%View Details
1446013-08-6 -
127464-43-1 99%View Details
127464-43-1 -
Chloro Uracil 99%View Details
1820-81-1 -
2-ETHYLPYRIDINE 100-71-0 99%View Details
100-71-0 -
13162-05-5 99%View Details
13162-05-5