1,8-Naphthyridine

CAS NO.：254-60-4
Empirical Formula: C8H6N2
Molecular Weight: 130.15
MDL number: MFCD00059751
SAFETY DATA SHEET (SDS)
Update Date: 2023-06-08 17:06:37

What is 1,8-Naphthyridine?

Description

1,8-Naphthyridine is an organic compound with the formula C8H6N2. It is the most well-studied of the six isomeric naphthyridines, a subset of diazanaphthalenes with nitrogen in the separate rings. Enoxacin, nalidixic acid, and trovafloxacin are 1,8-naphthyridine derivatives with antibacterial properties related to the fluoroquinolones.

The Uses of 1,8-Naphthyridine

1,8-naphthyridine (napy) and its simplest 2-methyl and 2,7-dimethyl derivatives may act as monodentate and bidentate ligands, resembling the behavior of the carboxylate ligands.

Definition

ChEBI: 1,8-naphthyridine is a naphthyridine in which the nitrogens are situated at positions 1 and 8.

Purification Methods

Purify 1,8-naphthyridine through an Al2O3 column and elute with toluene and pet ether, evaporate the eluate, crystallise the residue from pet ether (b 60-80o), and sublime it at 80o/13mm. The picrate [15936-16-0] has m 207-208o (from EtOH), and the methiodide has m 180-181o (from EtOH). [Hawes & Wibberley J Chem Soc (C) 1564 1967, UV: Armarego Physical Methods in Heterocyclic Chemistry (Ed Katritzky, Academic Press) Vol III 134 1971, Beilstein 23 II 178, 23 III/IV 1237.]

Properties of 1,8-Naphthyridine

Melting point:	99.8-99.9°C
Boiling point:	248.9±13.0 °C(Predicted)
Density	1.183±0.06 g/cm3(Predicted)
storage temp.	Sealed in dry,Room Temperature
form	powder to crystal
pka	3.55±0.10(Predicted)
pka	3.39
color	White to Light yellow to Light orange
CAS DataBase Reference	254-60-4(CAS DataBase Reference)

Safety information for 1,8-Naphthyridine

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.