18-HYDROXY-11-DEOXYCORTICOSTERONE
- CAS NO.：379-68-0
- Empirical Formula: C21H30O4
- Molecular Weight: 346.46
- MDL number: MFCD00010486
- EINECS: 2068343
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-05-25 18:00:55
What is 18-HYDROXY-11-DEOXYCORTICOSTERONE?
Description
18-hydroxy-11-deoxy Corticosterone (18-OH-DOC) is a mineralocorticoid secreted by the zona fasciculata of the adrenal gland. Its biosynthesis is regulated by adrenocorticotropic hormone (ACTH; ) as well as angiotensin II , which increases 18-OH-DOC production in isolated human adrenal glomerulosa cells. 18-OH-DOC can be formed via conversion of 11-deoxy corticosterone (DOC; ) in human SK-MEL188 melanoma cells. 18-OH-DOC is an intermediate in the metabolism of progesterone and can be converted to aldosterone by the capsular portion of rat adrenal glands. Continuous infusion of 18-OH-DOC (200 μg/rat per day) increases systolic blood pressure in uninephrectomized saline-drinking rats. Plasma levels of 18-OH-DOC are elevated in a db/db mouse model of type 2 diabetes.
The Uses of 18-HYDROXY-11-DEOXYCORTICOSTERONE
11-Deoxy-18-hydroxycorticosterone is an analog of Corticosterone (C695700); a glucocorticoid and intermediate in the biosynthesis of Aldosterone (A514700) which is an adrenocortical steroid isolated from the adrenal cortex.
Definition
ChEBI: 18-hydroxydeoxycorticosterone is a 21-hydroxy steroid, a 3-oxo-Delta(4) steroid, a 20-oxo steroid and a 18-hydroxy steroid.
Purification Methods
Recrystallise 18-hydroxy-11-deoxycorticosterone from Et2O/Me2CO to give crystals m 200-205o. When it is recrystallised from M2CO, it has m 191-195o. It has UV with max at 240nm. The 21-O-acetoxy-18-hydroxy derivative has m 158-159o (from Et2O/*C6H6), and the 21-O-acetoxy-18,20-epoxy derivative has m 149-154o (from Et2O). [Kahnt et al. Helv Chim Acta 38 1237 1955; Pappo J Am Chem Soc 81 1010 1959.]
Properties of 18-HYDROXY-11-DEOXYCORTICOSTERONE
| Melting point: | 171-173 °C |
| storage temp. | 2-8°C |
| solubility | Chloroform (Slightly, Sonicated), Methanol (Slightly, Heated) |
| form | Solid |
| color | White to Off-White |
Safety information for 18-HYDROXY-11-DEOXYCORTICOSTERONE
Computed Descriptors for 18-HYDROXY-11-DEOXYCORTICOSTERONE
New Products
Tubulysin E Tubulysin A Tubulysin C 2,2-diethoxyethanethioamide Potassium HMDS (1.0 M in THF) 4,4-DIFLUOROPIPERIDINE 3-Aminocyclobutanone hydrochloride 4,4-DIFLUOROCYCLOHEXANAMINE Methyl (R)-1-Boc-4,4-difluoropyrrolidine-2-carboxylate 2H-Pyran, 4-ethynyltetrahydro- tetrahydro-4-methyl-2H-pyran 2-[[(3aR,4S,6R,6aS)-6-Aminotetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]ethanol ethanedioate 2-[2-[3(S)-3[2-(7-chloro-2-quinolinyl) ethenyl] phenyl-3- hydroxyl propyl] phenyl]-2-propanol (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine 2-(1-(Mercaptomethyl) cyclopropyl) acetonitrile Calcium Sodium Phosphosilicate IH Imeglimin Hydrochloride IH Lubiprostone Latanoprostene Bunod Magnesium Trisilicate Flame Retardant Zinc Borate (R)-(3-(3-fluoro-4- thiomorpholinophenyl)-2- oxooxazolidin-4-yl) methyl methanesulfonate methyl 3-fluoro-4- thiomorpholino phenylcarbamate 7-Methoxyquinoline-4-carboxylic acidRelated products of tetrahydrofuran
![ALDOSTERONE, D [1,2,6,7-3H(N)]](https://img.chemicalbook.in/StructureFile/ChemBookStructure2/GIF/CB5458996.gif)
![ALDOSTERONE, D-[1,2-3H(N)]-](https://img.chemicalbook.in/StructureFile/ChemBookStructure2/GIF/CB5241895.gif)
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