17-PA
- CAS NO.:694438-95-4
- Empirical Formula: C25H34O
- Molecular Weight: 350.54
- MDL number: MFCD09971119
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-10-28 23:16:16
What is 17-PA?
The Uses of 17-PA
17-PA is an antagonist of neurosteroid GABA potentiation.
What are the applications of Application
17-PA is an antagonist of neurosteroid GABA potentiation
Biological Activity
Selective antagonist of neurosteroid potentiation and direct gating of GABA A receptors. Selectively reduces the effects of 5 α -reduced steroids compared to 5 β -reduced steroids and displays no effect on potentiation evoked by barbiturates and benzodiazepines. Attenuates 3 α ,5 α -THP-induced loss of righting reflex and total sleep time following i.c.v administration in rats.
Enzyme inhibitor
This selective neurosteroid antagonist (FW = 350.54 g/mol; CAS 694438- 95-4; Soluble to 25 mM in DMSO and to 50 mM in ethanol), also known as 17-PA, targets neurosteroid potentiation and directly gates GABAA receptors. 17-PA inhibition was also useful in demonstrating that ethanol modulates the interaction of the endogenous neurosteroid allopregnanolone with the α1β2γ2L GABAA receptor. 17-PA selectively reduces the effects of 5α-reduced steroids compared to 5β-reduced steroids and displays no effect on potentiation evoked by barbiturates and benzodiazepines. It also attenuates 3α,5α-THP-induced loss of righting reflex and total sleep time, following intracerebroventricular administration in rats.
Properties of 17-PA
storage temp. | Store at RT |
solubility | <8.76mg/ml in DMSO; <17.53mg/ml in ethanol |
Safety information for 17-PA
Computed Descriptors for 17-PA
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