15(S)-HETE
Synonym(s):(S)-15-HETE;(15S,5Z,8Z,11Z,13E)-15-Hydroxyeicosatetraenoic acid;15(S)-HETE
- CAS NO.:54845-95-3
- Empirical Formula: C20H32O3
- Molecular Weight: 320.47
- MDL number: MFCD00063590
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-06-08 09:03:04
What is 15(S)-HETE?
Description
15(S)-
The Uses of 15(S)-HETE
15(S)-HETE is a major arachidonic acid metabolite from the 15-lipoxygenase pathway. In mammals, 15(S)-HETE is synthesized in the respiratory epithelium, leukocytes, and reticulocytes. 15(S)-HETE is present in μg/ml concentrations in the nasal secretions of allergic rhinitis.
The Uses of 15(S)-HETE
15(S)-HETE is an arachidonic acid metabolite with immunosuppressive activity.
What are the applications of Application
15(S)-HETE is an arachidonic acid metabolite with immunosuppressive activity
Definition
ChEBI: An optically active form of 15-HETE having 15(S)-configuration..
General Description
15(S)-HETE is a product of the arachidonic acid pathway. It is synthesized by the human lungs and airway epithelial cells. 15(S)-HETE is a potent mucosecretagogue in human airways. It is a metabolite of 15-lipoxygenase. 15(S)-HETE is an endogenous ligand for peroxisome proliferator-activated receptor γ (PPARγ).
Biochem/physiol Actions
Metabolite of arachidonic acid via the 15-lipoxygenase pathway that may be involved in pulmonary anti-inflammatory responses through the inhibition of 5-lipoxygenase. 15(S)-HETE suppresses the incorporation of thymidine and biosynthesis of prostaglandin E2 in tumor cell cultures. Treatment of colon cancer cells with 15(S)-HETE inhibited cell proliferation and induced apoptosis, which was preceded by an increase in TGF-beta-inducible early gene (TIEG) and a decrease in Bcl-2.
Properties of 15(S)-HETE
Boiling point: | 487.7±45.0 °C(Predicted) |
Density | 0.984±0.06 g/cm3(Predicted) |
Flash point: | 14℃ |
storage temp. | -20°C |
solubility | 0.1 M Na2CO3: 2 mg/ml; DMF: Miscible; DMSO: Miscible; Ethanol: Miscible; PBS (pH 7.2): 0.8 mg/ml |
pka | 4.75±0.10(Predicted) |
form | Liquid. |
BRN | 2470466 |
Safety information for 15(S)-HETE
Signal word | Danger |
Pictogram(s) |
Flame Flammables GHS02 Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H225:Flammable liquids H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 15(S)-HETE
New Products
Tubulysin H Tubulysin E Tubulysin G Tubulysin F Tubulysin I 3-FLUOROPYRROLIDINE HYDROCHLORIDE 4-CYANO-TETRAHYDROPYRAN-4-CARBOXYLIC ACID 4-(Benzyloxy)-3-bromophenylacetic Acid 2-(azetidin-3-ylidene)acetonitrile (hydrochloride) CYCLOBUTYLAMINE HYDROCHLORIDE Methyl (R)-1-Boc-4,4-difluoropyrrolidine-2-carboxylate 2-[2-[3(S)-3[2-(7-chloro-2-quinolinyl) ethenyl] phenyl-3- hydroxyl propyl] phenyl]-2-propanol 2-(1-(Mercaptomethyl) cyclopropyl) acetonitrile (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine Fuel shell 2-[[(3aR,4S,6R,6aS)-6-Aminotetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]ethanol ethanedioate Imeglimin Hydrochloride IH Lubiprostone Latanoprostene Bunod Magnesium Trisilicate Flame Retardant Zinc Borate (R)-(3-(3-fluoro-4- thiomorpholinophenyl)-2- oxooxazolidin-4-yl) methyl methanesulfonate methyl 3-fluoro-4- thiomorpholino phenylcarbamate 1H-Imidazole-4-carbonitrileRelated products of tetrahydrofuran
You may like
-
15(S)-HETE CAS 54845-95-3View Details
54845-95-3 -
(R)-(3-(3-fluoro-4- thiomorpholinophenyl)-2- oxooxazolidin-4-yl) methyl methanesulfonateView Details
2416850-45-6 -
methyl 3-fluoro-4- thiomorpholino phenylcarbamateView Details
2760359-22-4 -
Fuel shell 98%View Details
-
4,6-dichloro-2-propylthiopyrimidine-5-amine 145783-15-9 98%View Details
145783-15-9 -
151767-02-1 Montelukast Sodium IP/USP 98%View Details
151767-02-1 -
Valacyclovir Hydrochloride IH 98%View Details
124832-27-5 -
2-[2-[3(S)-3[2-(7-chloro-2-quinolinyl) ethenyl] phenyl-3- hydroxyl propyl] phenyl]-2-propanol 98%View Details
142569-70-8