1,5-Pentanediol
Synonym(s):1,5-Pentanediol;Pentamethylene glycol
- CAS NO.:111-29-5
- Empirical Formula: C5H12O2
- Molecular Weight: 104.15
- MDL number: MFCD00002978
- EINECS: 203-854-4
- SAFETY DATA SHEET (SDS)
- Update Date: 2025-03-18 18:20:25

What is 1,5-Pentanediol?
Chemical properties
clear colorless oily liquid
The Uses of 1,5-Pentanediol
1,5-Pentanediol is used largely as a chemical intermediate. Industrial exposure is likely to be from direct contact.
The Uses of 1,5-Pentanediol
1,5-Pentanediol is used as a reagent in the total synthesis of (+)-Rubriflordilactone A, a nortriterpenoid natural product. 1,5-Pentanediol is also the starting material in the synthesis of Pseudomonic Acid D Sodium (P839520); an antibiotic isolated from Pseudomonas fluorescens.
Definition
ChEBI: Pentane-1,5-diol is a primary alcohol.
Synthesis Reference(s)
Journal of the American Chemical Society, 68, p. 1646, 1946 DOI: 10.1021/ja01212a085
Tetrahedron Letters, 21, p. 1501, 1980 DOI: 10.1016/S0040-4039(00)92757-6
Flammability and Explosibility
Not classified
Safety Profile
Mildly toxic by ingestion. A skin and eye irritant. Combustible when exposed to heat or flame; can react with oxidizing materials. To fight fire, use foam, CO2, dry chemical. Used as a plasticizer in cellulose products and adhesives, and in brake fluid.
Synthesis
1,5-Pentanediol usually is produced by catalytic hydrogenation of glutaric acid or of its esters, e.g., dimethyl glutarate, although dicarboxylic acid mixtures containing glutaric acid also may be used, giving typically a mixture of 1,4-butanediol, 1,5-pentanediol, and 1,6-hexanediol. A process using alkoxydihydropyrans as raw materials has also been reported. The crude products are purified by distillation.
Solubility in organics
1,5-Pentanediol is soluble in water, alcohols acetone, and relatively insoluble in aliphatic and aromatic hydrocarbons.
Properties of 1,5-Pentanediol
Melting point: | -18 °C |
Boiling point: | 242 °C (lit.) |
Density | 0.994 g/mL at 25 °C (lit.) |
vapor density | 3.59 |
vapor pressure | <0.01 mm Hg ( 20 °C) |
refractive index | n |
Flash point: | 135 °C |
storage temp. | Store below +30°C. |
solubility | Methanol (Slightly) |
form | Oily Liquid |
pka | 14.83±0.10(Predicted) |
color | Clear colorless |
Odor | odorless |
PH | 7.5 (H2O) |
explosive limit | 1.3-13.1%(V) |
Water Solubility | Miscible |
Sensitive | Hygroscopic |
Merck | 14,7117 |
BRN | 1560130 |
Dielectric constant | 25.300000000000001 |
CAS DataBase Reference | 111-29-5(CAS DataBase Reference) |
NIST Chemistry Reference | 1,5-Pentanediol(111-29-5) |
EPA Substance Registry System | 1,5-Pentanediol (111-29-5) |
Safety information for 1,5-Pentanediol
Signal word | Warning |
Pictogram(s) |
![]() Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up. |
Computed Descriptors for 1,5-Pentanediol
InChIKey | ALQSHHUCVQOPAS-UHFFFAOYSA-N |
1,5-Pentanediol manufacturer
CEFA CILINAS BIOTICS PVT LTD
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