4,13-Diaza-18-crown 6-ether

Synonym(s):1,10-Diaza-18-crown-6;1,7,10,16-Tetraoxa-4,13-diazacyclooctadecane;Kryptofix 22

CAS NO.：23978-55-4
Empirical Formula: C12H26N2O4
Molecular Weight: 262.35
MDL number: MFCD00005112
EINECS: 245-965-0
SAFETY DATA SHEET (SDS)
Update Date: 2024-04-01 18:08:31

What is 4,13-Diaza-18-crown 6-ether?

Chemical properties

off-white shiny crystalline powder

The Uses of 4,13-Diaza-18-crown 6-ether

1,4,10,13-Tetraoxa-7,16-diazacyclooctadecane is a crown ether, which can be used:

In the spectroscopic studies of its complex-forming reaction with iodine.
To prepare the ligand 7,16-bis(5-t-butyl-2-hydroxybenzyl)-1,4,10,13-tetraoxa-7,16-diazacyclooctadecane.
As a ligand in the study of zirconium facilitated hydrolysis of a dipeptide at neutral pH.

What are the applications of Application

1,4,10,13-Tetraoxa-7,16-diazacyclooctadecane is an ether

Purification Methods

Twice recrystallise it from *benzene/n-heptane, and dry it for 24hours under high vacuum [Weber & V.gtle Top Curr Chem (Springer Verlag, Berlin) 98 1 1981, D'Aprano & Sesta J Phys Chem 91 2415 1987].

Properties of 4,13-Diaza-18-crown 6-ether

Melting point:	111-114 °C(lit.)
Boiling point:	405.6°C (rough estimate)
Density	1.0807 (rough estimate)
refractive index	1.4560 (estimate)
storage temp.	Store below +30°C.
form	Shiny Crystalline Powder
pka	9.00±0.20(Predicted)
color	Off-white
Water Solubility	Soluble in water.
BRN	609764
CAS DataBase Reference	23978-55-4(CAS DataBase Reference)

Safety information for 4,13-Diaza-18-crown 6-ether

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.