1,4-Dibromopentane

CAS NO.：626-87-9
Empirical Formula: C5H10Br2
Molecular Weight: 229.94
MDL number: MFCD00000153
EINECS: 210-967-2
SAFETY DATA SHEET (SDS)
Update Date: 2023-12-28 18:13:10

What is 1,4-Dibromopentane?

Chemical properties

clear colorless to light yellow-brown liquid with a wine smell.

The Uses of 1,4-Dibromopentane

1,4-Dibromopentane is used in the preparation of pharaoh ant trail pheromone stereoisomer, indolizidine alkaloid. It is also involved in the preparation 1,2-dimethyl-1-phenylcyclopentane and boc-L-2-amino-6-bromoheptanoic acid.

Preparation

1,4-Dibromopentane is synthesized by ring-opening bromination of 2-methyltetrahydrofuran with hydrobromic acid and sulfuric acid. First, add hydrobromic acid into the reaction pot for cooling, slowly add 2-methyltetrahydrofuran and sulfuric acid in turn under stirring, and finish the addition when the temperature does not exceed 40°C. The temperature was raised to 60°C, reacted for 2h, and then reacted at 80-85°C for 4h. After cooling, the bromide was separated and washed with water until neutral to obtain 1,4-dibromopentane as an oily substance. Yield 92.5%.

Synthesis Reference(s)

Journal of the American Chemical Society, 74, p. 917, 1952 DOI: 10.1021/ja01124a016

Properties of 1,4-Dibromopentane

Melting point:	-34.4 °C (lit.)
Boiling point:	98-99 °C/25 mmHg (lit.)
Density	1.687 g/mL at 25 °C (lit.)
refractive index	n20/D 1.508
Flash point:	>110°C
storage temp.	2-8°C
form	clear liquid
color	Colorless to Light orange to Yellow
Specific Gravity	1.687
Water Solubility	Insoluble in water.
BRN	605295
CAS DataBase Reference	626-87-9(CAS DataBase Reference)
NIST Chemistry Reference	Pentane, 1,4-dibromo-(626-87-9)
EPA Substance Registry System	Pentane, 1,4-dibromo- (626-87-9)

Safety information for 1,4-Dibromopentane

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.