1,4-Bis(diphenylphosphino)butane
Synonym(s):1,4-Butanediylbis[diphenylphosphine];1,4-Butylenebis(diphenylphosphine);dppb;Tetramethylenebis(diphenylphosphine)
- CAS NO.：7688-25-7
- Empirical Formula: C28H28P2
- Molecular Weight: 426.47
- MDL number: MFCD00003051
- EINECS: 231-698-7
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-08-15 19:00:21
What is 1,4-Bis(diphenylphosphino)butane?
Description
1,4-Bis(diphenylphosphino)butane (Dppb) is a ligand typically used in palladium chemistry, but can also be used in chemistry involving other transition metals such as nickel or rhodium.
Chemical properties
white to light yellow crystal powde
The Uses of 1,4-Bis(diphenylphosphino)butane
1,4-Bis(diphenylphosphino)butane is used in Suzuki reaction. It plays an essential role as a ligand in palladium(0)-catalyzed acylcyanation of arylacetylenes and deprotection of allyloxycarbamates. It acts as a ligand for alkylations, isomerization reactions and in organometallic chemistry. Further, it is used in Heck reaction, Negishi coupling and Sonogashira coupling. In addition to this, it is useful in organometallic chemistry.
Purification Methods
Recrystallise it from EtOH [Trippett J Chem Soc 4263 1961]. [King J Coord Chem 1 62 1971, Tolman Chem Rev 77 313 1977.]
Properties of 1,4-Bis(diphenylphosphino)butane
| Melting point: | 132-136 °C (lit.) |
| Boiling point: | 542.0±33.0 °C(Predicted) |
| storage temp. | Inert atmosphere,Room Temperature |
| appearance | White solid |
| form | Crystalline Powder |
| color | White to almost white |
| Water Solubility | Soluble in chloroform. Slightly soluble in water |
| BRN | 706446 |
| CAS DataBase Reference | 7688-25-7(CAS DataBase Reference) |
| NIST Chemistry Reference | 1,4-Bis(diphenylphosphino)butane(7688-25-7) |
| EPA Substance Registry System | Phosphine, 1,4-butanediylbis[diphenyl- (7688-25-7) |
Safety information for 1,4-Bis(diphenylphosphino)butane
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 1,4-Bis(diphenylphosphino)butane
| InChIKey | BCJVBDBJSMFBRW-UHFFFAOYSA-N |
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![(+)-O-ISOPROPYLIDENE-2,3-DIHYDROXY-1,4-BIS[BIS(3,5-DIFLUOROMETHYLPHENYL)PHOSPHINO]BUTANE](https://img.chemicalbook.in/CAS/GIF/220196-30-5.gif)
RHODIUM(I) TETRA-FLUOROBORATE](https://img.chemicalbook.in/CAS/GIF/79255-71-3.gif)
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