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HomeProduct name list1,3,5[10]-ESTRATRIENE-3,16ALPHA-DIOL-17-ONE

1,3,5[10]-ESTRATRIENE-3,16ALPHA-DIOL-17-ONE

Synonym(s):1,3,5(10)-Estratriene-3,16α-diol-17-one;16α-3,16-Dihydroxyestra-1,3,5(10)-trien-17-one

  • CAS NO.:566-76-7
  • Empirical Formula: C18H22O3
  • Molecular Weight: 286.37
  • MDL number: MFCD00870436
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2023-05-18 11:31:16
1,3,5[10]-ESTRATRIENE-3,16ALPHA-DIOL-17-ONE Structural

What is 1,3,5[10]-ESTRATRIENE-3,16ALPHA-DIOL-17-ONE?

Description

The naturally-occurring estrogens are estrone (E1, ), estradiol (E2, ), and estriol (E3, ). 16α-hydroxy Estrone (16α-OHE1) is a hydroxylated metabolite of E1 as well as an interconversion product with E2. E1 is 16α-hydroxylated by cytochrome P450 (CYP) isoforms, including CYP1A1, CYP3A5, CYP3A4, and CYP3A7, with CYP3A5 being breast-specific. 16α-OHE1 is sulphatized or glucuronidated before excretion. It is increased in rheumatoid arthritis and decreased by physical activity. Unlike the parent estrogens and other hydroxylated metabolites of E1, 16α-OHE1 binds covalently and persistently activates estrogen receptors. In addition, this metabolite increases cell proliferation and does not suppress TNF-α secretion, whereas other estrogen metabolites are not pro-proliferative and have marked effects on TNF-α secretion. The levels of 16α-OHE1 are increased in some forms of hormone therapy. Because hormone therapy increases breast cancer risk, 16α-OHE1 has been implicated as a risk factor for breast cancer, although supportive data remains elusive.

Chemical properties

Pale Pink Solid

The Uses of 1,3,5[10]-ESTRATRIENE-3,16ALPHA-DIOL-17-ONE

A major metabolite of Estradiol

The Uses of 1,3,5[10]-ESTRATRIENE-3,16ALPHA-DIOL-17-ONE

16α-Hydroxy Estrone (Estriol EP Impurity H) is a major metabolite of Estradiol.

What are the applications of Application

16α-Hydroxy Estrone is a major Estradiol metabolite

Definition

ChEBI: The 16alpha-hydroxy derivative of estrone; a minor estrogen metabolite.

Properties of 1,3,5[10]-ESTRATRIENE-3,16ALPHA-DIOL-17-ONE

Melting point: 209-211°C
Boiling point: 493.2±45.0 °C(Predicted)
Density  1.249±0.06 g/cm3(Predicted)
storage temp.  -20°C Freezer
solubility  DMSO (Slightly), Ethanol (Slightly), Methanol (Slightly)
form  Solid
pka 10.23±0.60(Predicted)
color  White to Light Beige

Safety information for 1,3,5[10]-ESTRATRIENE-3,16ALPHA-DIOL-17-ONE

Signal word Danger
Pictogram(s)
ghs
Flame
Flammables
GHS02
ghs
Skull and Crossbones
Acute Toxicity
GHS06
ghs
Health Hazard
GHS08
GHS Hazard Statements H225:Flammable liquids
H370:Specific target organ toxicity, single exposure
Precautionary Statement Codes P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P370+P378:In case of fire: Use … for extinction.
P403+P235:Store in a well-ventilated place. Keep cool.

Computed Descriptors for 1,3,5[10]-ESTRATRIENE-3,16ALPHA-DIOL-17-ONE

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