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HomeProduct name list13,14-DIHYDRO-15-KETO PROSTAGLANDIN E1

13,14-DIHYDRO-15-KETO PROSTAGLANDIN E1

13,14-DIHYDRO-15-KETO PROSTAGLANDIN E1 Structural

What is 13,14-DIHYDRO-15-KETO PROSTAGLANDIN E1?

Description

13,14-dihydro-15-keto Prostaglandin E1 (PGE1) is a metabolite of PGE1 with much reduced biological activity. Steady state plasma concentrations are about 10 pg/ml. 13,14-dihydro-15-keto PGE1 is a weak inhibitor of ADP-induced platelet aggregation in human PRP and washed platelets with IC50 values of 54 and 200 μM, respectively, compared to PGE1 which has an IC50 of 40 nM.

The Uses of 13,14-DIHYDRO-15-KETO PROSTAGLANDIN E1

15-Keto Prostaglandin E0 is a metabolite of Prostaglandin E1 (P838600) and has been shown to induce arterial thromboresistance in experimental animals and in man, but with several magnitudes higher concentrations than Prostaglandin E1. 15-Keto Prostaglandin E0 is also used as the active ingredient in compositions used for the treatment of external secretion disorders.

What are the applications of Application

13,14-dihydro-15-keto Prostaglandin E1 is a metabolite of PGE1 with much reduced biological activity

Definition

ChEBI: 13,14-dihydro-15-oxoprostaglandin E1 is a prostaglandin E obtained by formal oxidation of the 15-hydroxy group and hydrogenation of the 13,14-double bond of prostaglandin E1. It has a role as a human xenobiotic metabolite. It is functionally related to a prostaglandin E1. It is a conjugate acid of a 13,14-dihydro-15-oxoprostaglandin E1(1-).

Properties of 13,14-DIHYDRO-15-KETO PROSTAGLANDIN E1

Boiling point: 537.2±35.0 °C(Predicted)
Density  1.072±0.06 g/cm3(Predicted)
storage temp.  -20°C Freezer, Under inert atmosphere
solubility  DMSO (Slightly), Methanol (Slightly), THF (Slightly)
form  Oil
pka 4.77±0.10(Predicted)
color  Dark Yellow

Safety information for 13,14-DIHYDRO-15-KETO PROSTAGLANDIN E1

Computed Descriptors for 13,14-DIHYDRO-15-KETO PROSTAGLANDIN E1

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