13,14-DIHYDRO-15-KETO PROSTAGLANDIN E1

CAS NO.：5094-14-4
Empirical Formula: C20H34O5
Molecular Weight: 354.49
MDL number: MFCD00135210
SAFETY DATA SHEET (SDS)
Update Date: 2023-05-18 11:31:17

What is 13,14-DIHYDRO-15-KETO PROSTAGLANDIN E1?

Description

13,14-dihydro-15-keto Prostaglandin E₁ (PGE₁) is a metabolite of PGE₁ with much reduced biological activity. Steady state plasma concentrations are about 10 pg/ml. 13,14-dihydro-15-keto PGE₁ is a weak inhibitor of ADP-induced platelet aggregation in human PRP and washed platelets with IC₅₀ values of 54 and 200 μM, respectively, compared to PGE₁ which has an IC₅₀ of 40 nM.

The Uses of 13,14-DIHYDRO-15-KETO PROSTAGLANDIN E1

15-Keto Prostaglandin E0 is a metabolite of Prostaglandin E1 (P838600) and has been shown to induce arterial thromboresistance in experimental animals and in man, but with several magnitudes higher concentrations than Prostaglandin E1. 15-Keto Prostaglandin E0 is also used as the active ingredient in compositions used for the treatment of external secretion disorders.

What are the applications of Application

13,14-dihydro-15-keto Prostaglandin E1 is a metabolite of PGE1 with much reduced biological activity

Definition

ChEBI: 13,14-dihydro-15-oxoprostaglandin E1 is a prostaglandin E obtained by formal oxidation of the 15-hydroxy group and hydrogenation of the 13,14-double bond of prostaglandin E1. It has a role as a human xenobiotic metabolite. It is functionally related to a prostaglandin E1. It is a conjugate acid of a 13,14-dihydro-15-oxoprostaglandin E1(1-).

Properties of 13,14-DIHYDRO-15-KETO PROSTAGLANDIN E1

Boiling point:	537.2±35.0 °C(Predicted)
Density	1.072±0.06 g/cm3(Predicted)
storage temp.	-20°C Freezer, Under inert atmosphere
solubility	DMSO (Slightly), Methanol (Slightly), THF (Slightly)
form	Oil
pka	4.77±0.10(Predicted)
color	Dark Yellow