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HomeProduct name list12(S)-HPETE

12(S)-HPETE

12(S)-HPETE Structural

What is 12(S)-HPETE?

Description

12(S)-HpETE is a monohydroperoxy polyunsaturated fatty acid (PUFA) produced by the action of platelet or leukocyte 12-lipoxygenase (12-LO) on arachidonic acid. It activates human blood leukocyte 5-LO, resulting in the synthesis of 5(S)-HETE, leukotriene B4 (LTB4), and 5(S),12(S)-DiHETE. Rat lung metabolizes 12(S)-HpETE to 8,11,12- and 10,11,12-trihydroxyeicostrienoic acids. 12(S)-HpETE is the mediator of many biological functions, including induction of c-fos and c-jun, activation of AP-1, and endothelium-dependent vasoconstriction. It mediates the inhibitory synaptic response to FMRF-amide in Aplysia sensory neurons and inhibits Ca2+/calmodulin-dependent protein kinase II from rat brain cortex.

The Uses of 12(S)-HPETE

12(S)-HPETE is a fatty acid and an activator of human blood leukocyte 5-LO.

What are the applications of Application

12(S)-HPETE is a fatty acid and an activator of human blood leukocyte 5-LO

Definition

ChEBI: 12(S)-HPETE is the (S)-enantiomer of 12-HPETE. It has a role as a mouse metabolite. It is functionally related to an icosa-5,8,10,14-tetraenoic acid. It is a conjugate acid of a 12(S)-HPETE(1-). It is an enantiomer of a 12(R)-HPETE.

Properties of 12(S)-HPETE

Boiling point: 518.0±50.0 °C(Predicted)
Density  1.013±0.06 g/cm3(Predicted)
storage temp.  Store at -20°C
solubility  0.1 M Na2CO3: 2 mg/ml; DMF: Miscible; DMSO: Miscible; Ethanol: Miscible; PBS pH 7.2: 0.8 mg/ml
form  Liquid.
pka 4.75±0.10(Predicted)

Safety information for 12(S)-HPETE

Computed Descriptors for 12(S)-HPETE

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