12(S)-HHT

Synonym(s):12(S)-HHT

CAS NO.：54397-84-1
Empirical Formula: C17H28O3
Molecular Weight: 280.4
MDL number: MFCD00057833
SAFETY DATA SHEET (SDS)
Update Date: 2024-07-02 08:54:58

What is 12(S)-HHT?

The Uses of 12(S)-HHT

12(S)-HHTrE is an unusual product of the cyclooxygenase (COX) pathway and one of the primary arachidonic acid metabolites of the human platelet. It is biosynthesized by thromboxane synthase (TX synthase) from prostaglandin H2 (PGH2) concurrently with TXA2. The biological role of 12(S)-HHTrE is uncertain. It is avidly oxidized to 12-oxoHTrE by porcine 15-hydroxy PGDH.

The Uses of 12(S)-HHT

12(S)-HHTrE is a metabolite of arachidonic acid (A765000), which is an essential fatty acid and a precursor in the biosynthesis of prostaglandins, thromboxanes, and leukotrienes. Arachidonic Acid occurs in liver, brain, glandular organs, and depot fats of animals, in small amounts in human depot fats, and Arachidonic Acid is also a constituent of animal phosphatides.

What are the applications of Application

12(S)-HHT is an inhibitor of human platelet aggregation and stimulator of prostacyclin production

Definition

ChEBI: A trienoic fatty acid that consists of (5Z,8E,10E)-heptadeca-5,8,10-trienoic acid bearing an additional 12S-hydroxy substituent.

Properties of 12(S)-HHT

Boiling point:	451.8±45.0 °C(Predicted)
Density	0.992±0.06 g/cm3(Predicted)
storage temp.	−20°C
solubility	0.1 M Na2CO3: 2 mg/ml; DMF: Miscible; DMSO: Miscible; Ethanol: Miscible; PBS pH 7.2: 0.8 mg/ml
form	ethanol solution
pka	4.75±0.10(Predicted)
color	Colorless to light yellow

Safety information for 12(S)-HHT

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.