1,1,4,4-Tetramethyl-1,2,3,4-tetrahydronaphthalene
- CAS NO.:6683-46-1
- Empirical Formula: C14H20
- Molecular Weight: 188.31
- MDL number: MFCD00052728
- EINECS: 229-723-1
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-12-18 14:08:52
What is 1,1,4,4-Tetramethyl-1,2,3,4-tetrahydronaphthalene?
The Uses of 1,1,4,4-Tetramethyl-1,2,3,4-tetrahydronaphthalene
1,1,4,4-Tetramethyl-1,2,3,4-tetrahydronaphthalene can be used as an intermediate to participate in a variety of chemical reactions and is used in the synthesis of a variety of compounds and drugs. For example, 6-lodo-1,1,4,4-tetramethyl-l,2,3,4-tetrahydronaphthalene, 6-bromo-1,1,4,4-tetramethyl-1,2,3,4-tetrahydronaphthalene and 1,1,4,4-tetramethyl-6-nitro-1,2,3,4- tetrahydronaphthalene and others.
Preparation
2,5-dichloro-2,5- dimethylhexane (300 mg, 1.64 mmol, 1 eq) was dissolved in dry benzene (25 mL). Then added AlCl3 (22.0 mg, 0.164 mmol, 0.1 eq) to the solution, which was stirred at reflux for 16 hours. The reaction was stopped with 3M HCl (5 mL) and extracted with hexanes (10 mL x 3). The combined organic layer was washed with brine, dried with Na2S04, filtered, and concentrated in vacuo. Finally, the crude was purified by flash chromatography (100% hexanes) to obtained the colourless oil (1,1,4,4-Tetramethyl-1,2,3,4-tetrahydronaphthalene).Yield=91%
Properties of 1,1,4,4-Tetramethyl-1,2,3,4-tetrahydronaphthalene
Melting point: | 115-120℃ |
Boiling point: | 63 °C |
Density | 0.9482 g/cm3(Temp: 27 °C) |
refractive index | 1.5278 (589.3 nm 27℃) |
storage temp. | 2-8°C |
color | Clear, pale yellow |
InChI | InChI=1S/C14H20/c1-13(2)9-10-14(3,4)12-8-6-5-7-11(12)13/h5-8H,9-10H2,1-4H3 |
EPA Substance Registry System | Naphthalene, 1,2,3,4-tetrahydro-1,1,4,4-tetramethyl- (6683-46-1) |
Safety information for 1,1,4,4-Tetramethyl-1,2,3,4-tetrahydronaphthalene
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 1,1,4,4-Tetramethyl-1,2,3,4-tetrahydronaphthalene
InChIKey | CCQKWSZYTOCEIB-UHFFFAOYSA-N |
SMILES | C1(C)(C)C2=C(C=CC=C2)C(C)(C)CC1 |
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