12-AMINODODECANOIC ACID

Synonym(s):12-Aminolauric acid

CAS NO.：693-57-2
Empirical Formula: C12H25NO2
Molecular Weight: 215.33
MDL number: MFCD00008153
EINECS: 211-754-7
SAFETY DATA SHEET (SDS)
Update Date: 2023-05-04 17:34:41

What is 12-AMINODODECANOIC ACID?

Description

12-Aminododecanoic acid is an alkane chain with terminal carboxlic acid and amine groups. The compound can be used as a PROTAC linker in the synthesis of PROTACs. The amino group (NH2) is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The terminal carboxylic acid can react with primary amine groups of activated NHS ester to form a stable amide bond.

Chemical properties

Light beige powder

The Uses of 12-AMINODODECANOIC ACID

12-Aminolauric Acid is an amino acid used as a reagent in organic synthesis of several compounds including phenylbutazone which is a new long-acting agent which displays improved pharmacokinectics based on human serum albumin as a drug carrier.

Definition

ChEBI: 12-aminododecanoic acid is an omega-amino fatty acid that is dodecanoic acid in which one of the terminal amino hydrogens has been replaced by an amino group. It has a role as a bacterial metabolite. It is an omega-amino fatty acid and a medium-chain fatty acid.

Flammability and Explosibility

Non flammable

Properties of 12-AMINODODECANOIC ACID

Melting point:	185-187 °C (lit.)
Boiling point:	349.7±15.0 °C(Predicted)
Density	0.957±0.06 g/cm3(Predicted)
vapor pressure	0Pa at 25℃
Flash point:	280 °C
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
solubility	Aqueous Acid (Slightly), Aqueous Base (Slightly)
form	Solid
pka	pK1: 4.648(+1) (25°C)
color	White to Off-White
Water Solubility	137mg/L at 20℃
BRN	907502
CAS DataBase Reference	693-57-2(CAS DataBase Reference)
EPA Substance Registry System	12-Aminolauric acid (693-57-2)