11BETA-PROSTAGLANDIN E1
- CAS NO.:27415-26-5
- Empirical Formula: C20H34O5
- Molecular Weight: 354.48
- MDL number: MFCD00084822
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-07-02 08:55:17
What is 11BETA-PROSTAGLANDIN E1?
Description
8-iso PGF2α is an isoprostane produced by the non-enzymatic peroxidation of arachidonic acid in membrane phospholipids. It is present in human plasma in two distinct forms - esterified in phospholipids and as the free acid. The ratio of these two forms is approximately 2:1, with a total plasma 8-iso PGF2α level of about 150 pg/ml in normal volunteers. In normal human urine, 8-iso PGF2α levels are about 180-200 pg/mg of creatinine. 8-iso PGF2α is a weak TP receptor agonist in vascular smooth muscle. Conversely, 8-iso PGF2α inhibits platelet aggregation induced by U-
Description
8-iso Prostaglandin F2α (8-iso PGF2α) is an isoprostane produced by the non-enzymatic peroxidation of arachidonic acid in membrane phospholipids. It is present in human plasma in two distinct forms - esterified in phospholipids and as the free acid. The ratio of these two forms is approximately 2:1, with a total plasma 8-iso PGF2α level of about 150 pg/ml in normal volunteers. In normal human urine, 8-iso PGF2α levels are about 180-200 pg/mg of creatinine. 8-iso PGF2α is a weak TP receptor agonist in vascular smooth muscle. Conversely, 8-iso PGF2α inhibits platelet aggregation induced by U-
8-iso Prostaglandin F2α MaxSpec® standard is a quantitative grade standard of 8-
The Uses of 11BETA-PROSTAGLANDIN E1
(8-epi-prostaglandin F2a) A major metabolite of PGF2α. A prostaglandin derivative used as a biomarker in the diagnosis and treatment of cardiovascular-related diseases as well as biomarkers of total body oxidative stress.
The Uses of 11BETA-PROSTAGLANDIN E1
A major metabolite of PGF2α. A prostaglandin derivative used as a biomarker in the diagnosis and treatment of cardiovascular-related diseases as well as biomarkers of total body oxidative stress.
What are the applications of Application
8-epi-Prostaglandin F2α is a potent vasoconstricting prostaglandin shown to agonize thromboxane receptors
Definition
ChEBI: A prostanoid that is prostaglandin F2alpha having inverted stereochemistry at the 8-position.
Properties of 11BETA-PROSTAGLANDIN E1
Boiling point: | 531.0±50.0 °C(Predicted) |
Density | 1.153±0.06 g/cm3(Predicted) |
storage temp. | Store at -20°C |
solubility | DMF: >100 mg/ml; DMSO: >100 mg/ml; Ethanol: >100 mg/ml; PBS pH 7.2: 3 mg/ml |
form | A crystalline solid |
pka | 4.76±0.10(Predicted) |
color | White to off-white |
Safety information for 11BETA-PROSTAGLANDIN E1
Computed Descriptors for 11BETA-PROSTAGLANDIN E1
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