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HomeProduct name list11BETA-PROSTAGLANDIN E1

11BETA-PROSTAGLANDIN E1

11BETA-PROSTAGLANDIN E1 Structural

What is 11BETA-PROSTAGLANDIN E1?

Description

8-iso PGF is an isoprostane produced by the non-enzymatic peroxidation of arachidonic acid in membrane phospholipids. It is present in human plasma in two distinct forms - esterified in phospholipids and as the free acid. The ratio of these two forms is approximately 2:1, with a total plasma 8-iso PGF level of about 150 pg/ml in normal volunteers. In normal human urine, 8-iso PGF levels are about 180-200 pg/mg of creatinine. 8-iso PGF is a weak TP receptor agonist in vascular smooth muscle. Conversely, 8-iso PGF inhibits platelet aggregation induced by U-46619 (10−6 M) and I-BOP (3 x 10−7 M) with IC50 values of 1.6 x 10−6 M and 1.8 x 10−6 M, respectively.

Description

8-iso Prostaglandin F (8-iso PGF) is an isoprostane produced by the non-enzymatic peroxidation of arachidonic acid in membrane phospholipids. It is present in human plasma in two distinct forms - esterified in phospholipids and as the free acid. The ratio of these two forms is approximately 2:1, with a total plasma 8-iso PGF level of about 150 pg/ml in normal volunteers. In normal human urine, 8-iso PGF levels are about 180-200 pg/mg of creatinine. 8-iso PGF is a weak TP receptor agonist in vascular smooth muscle. Conversely, 8-iso PGF inhibits platelet aggregation induced by U-46619 (10−6 M) and I-BOP (3 x 10−7 M) with IC50 values of 1.6 x 10−6 M and 1.8 x 10−6 M, respectively.

8-iso Prostaglandin F MaxSpec® standard is a quantitative grade standard of 8-iso Prostaglandin F that has been prepared specifically for mass spectrometry and related applications where quantitative reproducibility is required. The solution has been prepared gravimetrically and is supplied in a deactivated glass ampule sealed under argon. The concentration was verified by comparison to an independently prepared calibration standard. This 8-iso Prostaglandin F MaxSpec® standard is guaranteed to meet identity, purity, stability, and concentration specifications and is provided with a batch-specific certificate of analysis. Ongoing stability testing is performed to ensure the concentration remains accurate throughout the shelf life of the product. Note: The amount of solution added to the vial is in excess of the listed amount. Therefore, it is necessary to accurately measure volumes for preparation of calibration standards. Follow recommended storage and handling conditions to maintain product quality.

The Uses of 11BETA-PROSTAGLANDIN E1

(8-epi-prostaglandin F2a) A major metabolite of PGF2α. A prostaglandin derivative used as a biomarker in the diagnosis and treatment of cardiovascular-related diseases as well as biomarkers of total body oxidative stress.

The Uses of 11BETA-PROSTAGLANDIN E1

A major metabolite of PGF2α. A prostaglandin derivative used as a biomarker in the diagnosis and treatment of cardiovascular-related diseases as well as biomarkers of total body oxidative stress.

What are the applications of Application

8-epi-Prostaglandin F2α is a potent vasoconstricting prostaglandin shown to agonize thromboxane receptors

Definition

ChEBI: A prostanoid that is prostaglandin F2alpha having inverted stereochemistry at the 8-position.

Properties of 11BETA-PROSTAGLANDIN E1

Boiling point: 531.0±50.0 °C(Predicted)
Density  1.153±0.06 g/cm3(Predicted)
storage temp.  Store at -20°C
solubility  DMF: >100 mg/ml; DMSO: >100 mg/ml; Ethanol: >100 mg/ml; PBS pH 7.2: 3 mg/ml
form  A crystalline solid
pka 4.76±0.10(Predicted)
color  White to off-white

Safety information for 11BETA-PROSTAGLANDIN E1

Computed Descriptors for 11BETA-PROSTAGLANDIN E1

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