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HomeProduct name list1,1,2,2-Tetrafluoroethyl-2,2,3,3-tetrafluoropropylether

1,1,2,2-Tetrafluoroethyl-2,2,3,3-tetrafluoropropylether

  • CAS NO.:16627-68-2
  • Empirical Formula: C5H4F8O
  • Molecular Weight: 232.07
  • MDL number: MFCD00155961
  • EINECS: 605-433-4
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-19 20:33:22
1,1,2,2-Tetrafluoroethyl-2,2,3,3-tetrafluoropropylether Structural

What is 1,1,2,2-Tetrafluoroethyl-2,2,3,3-tetrafluoropropylether?

Description

1,1,2,2-Tetrafluoroethyl-2,2,3,3-tetrafluoropropyl ether (HFE-458) is a hydrofluoroether. Hydrofluoroether is a new type of Chemicalbook chlorofluorocarbons (CFCs) substitute, ODP is zero, GWP is low, and the atmospheric residence time is very short. It is considered as one of the ideal substitutes for CFCs.

The Uses of 1,1,2,2-Tetrafluoroethyl-2,2,3,3-tetrafluoropropylether

1,1,2,2-Tetrafluoroethyl-2,2,3,3-tetrafluoropropylether can be used as organic synthesis intermediates and pharmaceutical intermediates, mainly used in laboratory research and development processes and chemical production processes.

Synthesis

Synthesis_16627-68-2
A system of a 6-L autoclave made of stainless steel was evacuated. The autoclave was charged with 401 g of potassium hydroxide (7.15 mol, 0.55 molar amount relative to 1 mol of a fluorine-containing alkyl alcohol), water (1604 mL), 2,2,3,3-tetrafluoro-1-propanol (boiling point of 109?? C., specific gravity of 1.4) represented by HCF2CF2CH2OH (1716 g, 13 mol) as a fluorine-containing alkyl alcohol. Then, the system was evacuated and replaced with nitrogen 20 times at room temperature. After evacuated, the system was filled with tetrafluoroethylene to 0.1 MPa, and the reaction system was heated to 85?? C. After the temperature in the system reached 85?? C., tetrafluoroethylene was added thereto little by little so that the reaction pressure was kept at 0.5 to 0.8 MPa. The temperature in the system was adjusted so as to be kept at 75 to 95?? C.Tetrafluoroethylene was added until the amount reached 0.5 molar relative to 1 mol of the fluorine-containing alkyl alcohol. The reaction was continuously carried out under stirring. When reduction in the pressure in the autoclave was stopped, the temperature in the autoclave was reduced to room temperature and unreacted tetrafluoroethylene was discharged, and the reaction was stopped. These steps took 5 hours to perform.The fluoroether of a lower phase of the production solution was HCF2CF2CH2OCF2CF2H (boiling point of 92?? C., specific gravity of 1.52). Table 1 shows the composition of the fluoroether production solution of a lower phase resulting from GC analysis.

Properties of 1,1,2,2-Tetrafluoroethyl-2,2,3,3-tetrafluoropropylether

Boiling point: 92 °C
Density  1.533
refractive index  1.29
Flash point: 27.5 °C
storage temp.  Sealed in dry,Room Temperature
form  clear liquid
Specific Gravity 1.533
color  Colorless to Almost colorless
InChI InChI=1S/C5H4F8O/c6-2(7)4(10,11)1-14-5(12,13)3(8)9/h2-3H,1H2
CAS DataBase Reference 16627-68-2(CAS DataBase Reference)
EPA Substance Registry System (2H-Perfluoroethyl)(1H,1H,3H-perfluoropropyl)ether (16627-68-2)

Safety information for 1,1,2,2-Tetrafluoroethyl-2,2,3,3-tetrafluoropropylether

Signal word Warning
Pictogram(s)
ghs
Flame
Flammables
GHS02
GHS Hazard Statements H226:Flammable liquids
Precautionary Statement Codes P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P233:Keep container tightly closed.
P240:Ground/bond container and receiving equipment.
P241:Use explosion-proof electrical/ventilating/lighting/…/equipment.
P242:Use only non-sparking tools.
P243:Take precautionary measures against static discharge.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P370+P378:In case of fire: Use … for extinction.
P403+P235:Store in a well-ventilated place. Keep cool.

Computed Descriptors for 1,1,2,2-Tetrafluoroethyl-2,2,3,3-tetrafluoropropylether

InChIKey HCBRSIIGBBDDCD-UHFFFAOYSA-N
SMILES C(F)(F)C(F)(F)COC(F)(F)C(F)F

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