1-Tetralone

Synonym(s):α-Tetralone;1,2,3,4-Tetrahydro-1-naphthalenone;3,4-Dihydro-1(2H)-naphthalenone;alpha-Tetralone

CAS NO.：529-34-0
Empirical Formula: C10H10O
Molecular Weight: 146.19
MDL number: MFCD00001688
EINECS: 208-460-6
SAFETY DATA SHEET (SDS)
Update Date: 2025-03-06 15:22:15

What is 1-Tetralone?

Chemical properties

Clear amber to brown oily liquid

The Uses of 1-Tetralone

1-Tetralone is a reagent used in the synthesis of amino-pyrazolopyridines with anti-NF-κB and pro-apoptotic potential.

Synthesis Reference(s)

Tetrahedron Letters, 32, p. 4291, 1991 DOI: 10.1016/S0040-4039(00)92151-8

Purification Methods

Check the IR first. Purify α-tetralone by dissolving 20mL in Et2O (200mL), washing with H2O (100mL), 5% aqueous NaOH (100mL), H2O (100mL), 3% aqueous AcOH (100mL), 5% NaHCO3 (100mL) then H2O (100mL) and dry the ethereal layer over MgSO4. Filter, evaporate and fractionate the residue through a 6in Vigreux column (p 11) under reduced pressure to give a colourless oil (~17g) with b 90-91o/0.50.7mm. [Snyder & Werber Org Synth Coll Vol III 798 1955.] It has also been fractionated through a 0.5metre packed column with a heated jacket under reflux using a partial take-off head. It has max 247.5 and 290nm (hexane). The phenylhydrazone has m 83o. The 2,4,6-trinitrophenylhydrazone has m 247.5-248o (from EtOH). [Olson & Bader Org Synth Coll Vol IV 898 1963, Beilstein 7 H 370, 7 III 1416, 7 IV 1015.]

Properties of 1-Tetralone

Melting point:	2-7 °C(lit.)
Boiling point:	113-116 °C6 mm Hg(lit.)
Density	1.099 g/mL at 25 °C(lit.)
refractive index	n20/D 1.568(lit.)
Flash point:	>230 °F
storage temp.	2-8°C
solubility	Chloroform, Ethyl Acetate (Slightly)
form	Liquid
color	brown
Water Solubility	insoluble
BRN	607374
CAS DataBase Reference	529-34-0(CAS DataBase Reference)
NIST Chemistry Reference	1(2H)-Naphthalenone, 3,4-dihydro-(529-34-0)
EPA Substance Registry System	1,2,3,4-Tetrahydronaphthalen-1-one (529-34-0)

Safety information for 1-Tetralone

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral
Precautionary Statement Codes	P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P501:Dispose of contents/container to..…