1-Methyl-1H-indole-3-carboxylic acid
- CAS NO.：32387-21-6
- Empirical Formula: C10H9NO2
- Molecular Weight: 175.18
- MDL number: MFCD01321244
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-09-19 18:11:18
What is 1-Methyl-1H-indole-3-carboxylic acid?
Chemical properties
Off-white solid
The Uses of 1-Methyl-1H-indole-3-carboxylic acid
- Reactant for preparation of bisindolyl pyrimidinones analogs of PKC inhibitor LY333531
- Reactant for preparation of (heteroaryl)(carboxamido)arylpyrrole derivatives as Cdc7 kinase inhibitors, antitumor and antiproliferative agents
- Reactant for preparation of (pyrrolidinylmethoxy)cyclohexanecarboxylic acids as antigen-4 (VLA-4) antagonists
- Reactant for preparation of EphB3 receptor tyrosine kinase inhibitors
- Reactant for preparation of pyrazolodiazepine derivatives as human P2X7 receptor antagonists
- Reactant for preparation of potent nonpeptidic urotensin II receptor agonists
- Reactant for preparation of pyrrolizidine esters, amides, and ureas as 5-HT4 receptor ligands
What are the applications of Application
1-Methylindole-3-carboxylic acid is a useful reactant for the preparation of PKC inhibitors, CDC kinase inhibitors, and other inhibitors
General Description
1-Methylindole-3-carboxylic acid is an indole derivative that can be prepared by the oxidation of 1-methylindole-3-aldehyde with alkaline potassium permanganate.
Properties of 1-Methyl-1H-indole-3-carboxylic acid
| Melting point: | 197-200 °C (dec.) (lit.) |
| Boiling point: | 389.0±15.0 °C(Predicted) |
| Density | 1.24±0.1 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| form | Crystalline Powder |
| pka | 4.01±0.10(Predicted) |
| color | White to beige |
| CAS DataBase Reference | 32387-21-6(CAS DataBase Reference) |
Safety information for 1-Methyl-1H-indole-3-carboxylic acid
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 1-Methyl-1H-indole-3-carboxylic acid
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