1-Methyl-1H-indole-3-carboxylic acid

CAS NO.：32387-21-6
Empirical Formula: C10H9NO2
Molecular Weight: 175.18
MDL number: MFCD01321244
SAFETY DATA SHEET (SDS)
Update Date: 2024-09-19 18:11:18

What is 1-Methyl-1H-indole-3-carboxylic acid?

Chemical properties

Off-white solid

The Uses of 1-Methyl-1H-indole-3-carboxylic acid

Reactant for preparation of bisindolyl pyrimidinones analogs of PKC inhibitor LY333531
Reactant for preparation of (heteroaryl)(carboxamido)arylpyrrole derivatives as Cdc7 kinase inhibitors, antitumor and antiproliferative agents
Reactant for preparation of (pyrrolidinylmethoxy)cyclohexanecarboxylic acids as antigen-4 (VLA-4) antagonists
Reactant for preparation of EphB3 receptor tyrosine kinase inhibitors
Reactant for preparation of pyrazolodiazepine derivatives as human P2X7 receptor antagonists
Reactant for preparation of potent nonpeptidic urotensin II receptor agonists
Reactant for preparation of pyrrolizidine esters, amides, and ureas as 5-HT4 receptor ligands

What are the applications of Application

1-Methylindole-3-carboxylic acid is a useful reactant for the preparation of PKC inhibitors, CDC kinase inhibitors, and other inhibitors

General Description

1-Methylindole-3-carboxylic acid is an indole derivative that can be prepared by the oxidation of 1-methylindole-3-aldehyde with alkaline potassium permanganate.

Properties of 1-Methyl-1H-indole-3-carboxylic acid

Melting point:	197-200 °C (dec.) (lit.)
Boiling point:	389.0±15.0 °C(Predicted)
Density	1.24±0.1 g/cm3(Predicted)
storage temp.	Sealed in dry,Room Temperature
form	Crystalline Powder
pka	4.01±0.10(Predicted)
color	White to beige
CAS DataBase Reference	32387-21-6(CAS DataBase Reference)

Safety information for 1-Methyl-1H-indole-3-carboxylic acid

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.