1-HYDROXY-1-CYCLOHEXANECARBONITRILE

The Uses of 1-HYDROXY-1-CYCLOHEXANECARBONITRILE

Cyclohexanone cyanohydrin was employed as substrate during high-throughput screening assay for hydroxynitrile lyase activity. It was used in preparation of 1-aminomethyl cyclohexanol via catalytic hydrogenation reaction.

Synthesis Reference(s)

Tetrahedron Letters, 19, p. 3773, 1978 DOI: 10.1016/S0040-4039(01)95055-5

General Description

Brown solid.

Air & Water Reactions

Water soluble. Reacts slowly with water .

Reactivity Profile

1-HYDROXY-1-CYCLOHEXANECARBONITRILE is an a-hydroxonitrile. Incompatible with acids; mixing nitriles with strong oxidizing acids can lead to violent reactions. Incompatible with oxidizing agents such as peroxides and epoxides. Mixing with bases can produce poisonous and flammable hydrogen cyanide. May be hydrolyzed exothermically in both aqueous acid and base to give carboxylic acids (or salts of carboxylic acids). May react vigorously with reducing agents.

Fire Hazard

Flash point data regarding 1-HYDROXY-1-CYCLOHEXANECARBONITRILE are not available, however, 1-HYDROXY-1-CYCLOHEXANECARBONITRILE is probably combustible.