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HomeProduct name list1-CYANOCYCLOBUTANECARBOXYLIC ACID ETHYL ESTER

1-CYANOCYCLOBUTANECARBOXYLIC ACID ETHYL ESTER

1-CYANOCYCLOBUTANECARBOXYLIC ACID ETHYL ESTER Structural

What is 1-CYANOCYCLOBUTANECARBOXYLIC ACID ETHYL ESTER?

The Uses of 1-CYANOCYCLOBUTANECARBOXYLIC ACID ETHYL ESTER

1-CYANOCYCLOBUTANECARBOXYLIC ACID ETHYL ESTER can be used as organic synthesis intermediate and pharmaceutical intermediate, mainly used in laboratory research and development process and chemical and pharmaceutical production process.

Synthesis

Synthesis_28246-87-9
4-(9>-cyclopentyl-5'-methyl-6>-oxo-5>,6>,8>,9>- tetrahydrospiro[cyclobutane-l,7'-pyrimido[4,5-b][l,4]diazepine]-2'-ylamino)-3- methoxybenzoic acid; [0521] Ethyl 1-cyanocyclobutanecarboxylate; To a solution of sodium ethoxide (21wt% in EtOH, 5.79 rnL, 15.5 mmol) in EtOH (25 mL), was added ethyl cyanoacetate(1.12 mL, 10.5 mmol), followed shortly thereafter by 1,1-dibromopropane (1.12 mL, 10 mmol). The reaction mixture was refluxed for 3 hrs. It was then concentrated, and diluted to ethyl acetate. The organic layer was washed with NaHCCh, brine, water, dried over Na2SO4 and concentrated in vacuo to obtain ethyl 1-cyanocyclobutanecarboxylate (1.17 g, 74% yield) as a red liquid. It was used directly for next step reaction.

Properties of 1-CYANOCYCLOBUTANECARBOXYLIC ACID ETHYL ESTER

Boiling point: 215.5-216 °C(Press: 762 Torr)
Density  1.09±0.1 g/cm3(Predicted)
storage temp.  Sealed in dry,Room Temperature

Safety information for 1-CYANOCYCLOBUTANECARBOXYLIC ACID ETHYL ESTER

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
Precautionary Statement Codes P280:Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352:IF ON SKIN: wash with plenty of soap and water.

Computed Descriptors for 1-CYANOCYCLOBUTANECARBOXYLIC ACID ETHYL ESTER

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