1-CYANOCYCLOBUTANECARBOXYLIC ACID ETHYL ESTER
- CAS NO.:28246-87-9
- Empirical Formula: C8H11NO2
- Molecular Weight: 153.18
- MDL number: MFCD04114273
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-04-27 16:27:43
What is 1-CYANOCYCLOBUTANECARBOXYLIC ACID ETHYL ESTER?
The Uses of 1-CYANOCYCLOBUTANECARBOXYLIC ACID ETHYL ESTER
1-CYANOCYCLOBUTANECARBOXYLIC ACID ETHYL ESTER can be used as organic synthesis intermediate and pharmaceutical intermediate, mainly used in laboratory research and development process and chemical and pharmaceutical production process.
Synthesis
4-(9>-cyclopentyl-5'-methyl-6>-oxo-5>,6>,8>,9>- tetrahydrospiro[cyclobutane-l,7'-pyrimido[4,5-b][l,4]diazepine]-2'-ylamino)-3- methoxybenzoic acid; [0521] Ethyl 1-cyanocyclobutanecarboxylate; To a solution of sodium ethoxide (21wt% in EtOH, 5.79 rnL, 15.5 mmol) in EtOH (25 mL), was added ethyl cyanoacetate(1.12 mL, 10.5 mmol), followed shortly thereafter by 1,1-dibromopropane (1.12 mL, 10 mmol). The reaction mixture was refluxed for 3 hrs. It was then concentrated, and diluted to ethyl acetate. The organic layer was washed with NaHCCh, brine, water, dried over Na2SO4 and concentrated in vacuo to obtain ethyl 1-cyanocyclobutanecarboxylate (1.17 g, 74% yield) as a red liquid. It was used directly for next step reaction.
Properties of 1-CYANOCYCLOBUTANECARBOXYLIC ACID ETHYL ESTER
Boiling point: | 215.5-216 °C(Press: 762 Torr) |
Density | 1.09±0.1 g/cm3(Predicted) |
storage temp. | Sealed in dry,Room Temperature |
Safety information for 1-CYANOCYCLOBUTANECARBOXYLIC ACID ETHYL ESTER
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
Precautionary Statement Codes |
P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. |
Computed Descriptors for 1-CYANOCYCLOBUTANECARBOXYLIC ACID ETHYL ESTER
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