1-Chloro-4-fluorobenzene

CAS NO.：352-33-0
Empirical Formula: C6H4ClF
Molecular Weight: 130.55
MDL number: MFCD00000603
EINECS: 206-521-1
SAFETY DATA SHEET (SDS)
Update Date: 2025-09-25 17:15:13

What is 1-Chloro-4-fluorobenzene?

Chemical properties

Clear colourless to light yellow liquid

The Uses of 1-Chloro-4-fluorobenzene

1-Chloro-4-fluorobenzeneis used as a primary and secondary intermediates, organic synthesis. And it is also used to prepare (4'-fluoro-biphenyl-4-yl)-methyl ether by using reagents NaH, Ni (OAc)2, 2,2 '-bipyridyl, KI and solvents benzene, tetrahydrofuran at temperature of 63°C.

Properties of 1-Chloro-4-fluorobenzene

Melting point:	-21.5 °C
Boiling point:	129-130 °C(lit.)
Density	1.226 g/mL at 25 °C(lit.)
refractive index	n20/D 1.495(lit.)
Flash point:	85 °F
storage temp.	Flammables area
solubility	Difficult to mix.
form	Liquid
color	Clear colorless to slightly yellow
Specific Gravity	1.226
BRN	1904542
CAS DataBase Reference	352-33-0(CAS DataBase Reference)
NIST Chemistry Reference	Benzene, 1-chloro-4-fluoro-(352-33-0)
EPA Substance Registry System	Benzene, 1-chloro-4-fluoro- (352-33-0)

Safety information for 1-Chloro-4-fluorobenzene

Signal word	Warning
Pictogram(s)	Flame Flammables GHS02 Exclamation Mark Irritant GHS07
GHS Hazard Statements	H226:Flammable liquids H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.