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HomeProduct name list1-Bromo-3-chloropropane

1-Bromo-3-chloropropane

Synonym(s):1-Bromo-3-chloropropane;1-Chloro-3-bromopropane;I-BCP;Trimethylene bromochloride;Trimethylene chlorobromide

  • CAS NO.:109-70-6
  • Empirical Formula: C3H6BrCl
  • Molecular Weight: 157.44
  • MDL number: MFCD00000998
  • EINECS: 203-697-1
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-08-21 22:41:43
1-Bromo-3-chloropropane Structural

What is 1-Bromo-3-chloropropane?

Description

1-Bromo-3-chloropropane is a halogenated alkane compound containing one bromine atom and one chlorine atom in its structure. Due to the high electronegativity of halogens, the molecule of 1-Bromo-3-chloropropane is highly electrophilic and is easily attacked by electrophilic reagents such as nucleophilic reagents, Lewis acid, etc., which undergoes nucleophilic substitution reactions. The compound is relatively stable at room temperature, but is susceptible to elimination reactions at high temperatures or in the presence of strong acids or bases. In addition, prolonged exposure to air should be avoided because 1-Bromo-3-chloropropane molecules contain halogen atoms that are susceptible to reaction by oxygen and moisture in the air to produce products such as alcohols and aldehydes.

Chemical properties

It is a clear and colorless liquid that is soluble in ethanol, ether, and chloroform but insoluble in water.

The Uses of 1-Bromo-3-chloropropane

1-Bromo-3-chloropropane can be used safer and equally efficient alternative to chloroform as a phase-separation agent in the 1-step method of RNA isolation from biological samples such as animal and plant tissue. It is a replacement for CHCl3 in RNA phase separations.

What are the applications of Application

1-Bromo-3-chloropropane is a replacement for CHCl3 in RNA phase separations

Preparation

The most common method for producing 1-Bromo-3-chloropropane is through the free-radical addition of anhydrous hydrogen bromide to allyl chloride. Alternatively, it can be prepared by reacting ethylene with methylene chlorobromide.

Definition

ChEBI: 1-Bromo-3-chloropropane (I-BCP or 109-70-6) is an organochlorine compound that can be used as a safer and equally effective alternative to chloroform. It serves as a phase-separation agent for the one-step method of RNA isolation from biological samples like animal and plant tissue. I-BCP can replace CHCl3 in RNA phase separations.

General Description

1-bromo-3-chloropropane appears as a colorless liquid. Insoluble in water and denser than water. May be toxic by inhalation, ingestion or skin absorption. Used to make pharmaceuticals and other chemicals.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

Halogenated aliphatic compounds, such as 1-Bromo-3-chloropropane, are moderately or very reactive. Reactivity generally decreases with increased degree of substitution of halogen for hydrogen atoms. Materials in this group are incompatible with strong oxidizing and reducing agents. Also, they are incompatible with many amines, nitrides, azo/diazo compounds, alkali metals, and epoxides.

Health Hazard

Inhalation of vapors or dust is extremely irritating. May cause burning of eyes and flow of tears. May cause coughing, difficult breathing and nausea. Brief exposure effects last only a few minutes. Exposure in an enclosed area may be very harmful. Fire will produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may cause pollution.

Fire Hazard

Some of these materials may burn, but none ignite readily. Containers may explode when heated.

Safety Profile

Moderately toxic by ingestion. When heated to decomposition it emits toxic fumes of Cland Br-. See also CHLORINATED HYDROCARBONS, ALIPHATIC; and BROMIDES.

Purification Methods

Wash it with conc H2SO4, water, 10% Na2CO3 solution, water again and then dry with CaCl2 and fractionally distil it just before use [Akagi et al. J Am Chem Soc 78 4034 1956]. [Beilstein 1 H 109, 1 IV 212.]

Properties of 1-Bromo-3-chloropropane

Melting point: -59 °C
Boiling point: 144-145 °C (lit.)
Density  1.592 g/mL at 25 °C (lit.)
vapor pressure  7.5 hPa (20 °C)
refractive index  n20/D 1.486(lit.)
Flash point: 81 °C
storage temp.  room temp
solubility  2.24g/l insoluble
form  liquid
color  Clear liquid
explosive limit 3.2-8.6%(V)
Water Solubility  insoluble
BRN  605278
Stability: Volatile
CAS DataBase Reference 109-70-6(CAS DataBase Reference)
IARC 2B (Vol. 125)
NIST Chemistry Reference Propane, 1-bromo-3-chloro-(109-70-6)
EPA Substance Registry System Propane, 1-bromo-3-chloro- (109-70-6)

Safety information for 1-Bromo-3-chloropropane

Signal word Danger
Pictogram(s)
ghs
Skull and Crossbones
Acute Toxicity
GHS06
ghs
Health Hazard
GHS08
GHS Hazard Statements H302:Acute toxicity,oral
H331:Acute toxicity,inhalation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
H341:Germ cell mutagenicity
H350:Carcinogenicity
H412:Hazardous to the aquatic environment, long-term hazard
Precautionary Statement Codes P202:Do not handle until all safety precautions have been read and understood.
P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P273:Avoid release to the environment.
P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P308+P313:IF exposed or concerned: Get medical advice/attention.

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