1-Bromo-2,5-difluorobenzene

CAS NO.：399-94-0
Empirical Formula: C6H3BrF2
Molecular Weight: 192.99
MDL number: MFCD00000345
EINECS: 206-920-0
SAFETY DATA SHEET (SDS)
Update Date: 2024-11-04 20:04:50

What is 1-Bromo-2,5-difluorobenzene?

Chemical properties

CLEAR COLOURLESS LIQUID

The Uses of 1-Bromo-2,5-difluorobenzene

2-Bromo-1,4-difluorobenzene has been used in the preparation of 1,4-difluoroanthraquinone, a precursor to ametantrone.

General Description

Lithiation of 2-bromo-1,4-difluorobenzene in the presence of lithium diisopropylamide (LDA) in THF-hexane, butyllithium in diethyl ether-hexane and butyllithium in THF-hexane has been reported.

Properties of 1-Bromo-2,5-difluorobenzene

Melting point:	−31 °C(lit.)
Boiling point:	58-59 °C20 mm Hg(lit.)
Density	1.708 g/mL at 25 °C(lit.)
refractive index	n20/D 1.508(lit.)
Flash point:	149 °F
storage temp.	Sealed in dry,Room Temperature
form	clear liquid
color	Colorless to Light yellow to Light orange
Specific Gravity	1.708
Water Solubility	Insoluble
BRN	1680893
InChI	InChI=1S/C6H3BrF2/c7-5-3-4(8)1-2-6(5)9/h1-3H
CAS DataBase Reference	399-94-0(CAS DataBase Reference)
NIST Chemistry Reference	Benzene, 2-bromo-1,4-difluoro-(399-94-0)

Safety information for 1-Bromo-2,5-difluorobenzene

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.