1-Bromo-2-nitrobenzene
- CAS NO.：577-19-5
- Empirical Formula: C6H4BrNO2
- Molecular Weight: 202.01
- MDL number: MFCD00007045
- EINECS: 209-409-0
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-05-15 10:43:17
What is 1-Bromo-2-nitrobenzene?
Chemical properties
white to light yellow crystal powder
The Uses of 1-Bromo-2-nitrobenzene
1-Bromo-2-nitrobenzene is used in organic synthesis. It also can react with 2-methylamino-benzoic acid to get N-methyl-N-(2-nitro-phenyl)-anthranilic acid. And it is also used in the preparation of 4-methoxy-2?-nitrodiphenyl ether, 1-methoxy-3,5-bis-(2-nitro-phenoxy)benzene.
The Uses of 1-Bromo-2-nitrobenzene
1-Bromo-2-nitrobenzene may be used in the preparation of:
- 4-methoxy-2′-nitrodiphenyl ether
- 1-methoxy-3,5-bis-(2-nitro-phenoxy)benzene
- 5-hydroxy-3-methoxy-2′-nitrodiphenyl ether
General Description
1-Bromo-2-nitrobenzene undergoes palladium[0]-mediated Ullmann cross-coupling reaction with a range of β-halo-enals, -enones or -esters to afford the corresponding β-aryl derivatives. Palladium[0]-mediated Ullmann cross-coupling reaction of 1-bromo-2-nitrobenzene with β-bromo-α,β-unsaturated aldehydes is reported.
Purification Methods
Crystallise it twice from pet ether, using charcoal before the first crystallisation. [Beilstein 5 III 618, 5 IV 728.]
Properties of 1-Bromo-2-nitrobenzene
| Melting point: | 40-42 °C (lit.) |
| Boiling point: | 261 °C (lit.) |
| Density | 1.7 g/cm3 (20℃) |
| refractive index | 1.6060 (estimate) |
| Flash point: | >230 °F |
| storage temp. | 2-8°C |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| form | powder to crystal |
| color | Light yellow to Amber to Dark green |
| Water Solubility | insoluble |
| BRN | 2044109 |
| Stability: | Stable. Combustible. Incompatible with strong bases, strong oxidizing agents. |
| CAS DataBase Reference | 577-19-5(CAS DataBase Reference) |
| NIST Chemistry Reference | Benzene, 1-bromo-2-nitro-(577-19-5) |
| EPA Substance Registry System | o-Bromonitrobenzene (577-19-5) |
Safety information for 1-Bromo-2-nitrobenzene
| Signal word | Warning |
| Pictogram(s) |
 Skull and Crossbones Acute Toxicity GHS06  Exclamation Mark Irritant GHS07  Health Hazard GHS08 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H312:Acute toxicity,dermal H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H331:Acute toxicity,inhalation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation H373:Specific target organ toxicity, repeated exposure |
| Precautionary Statement Codes |
P260:Do not breathe dust/fume/gas/mist/vapours/spray. P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P501:Dispose of contents/container to..… |
Computed Descriptors for 1-Bromo-2-nitrobenzene
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