1-Boc-Azetidine-3-yl-methanol

CAS NO.：142253-56-3
Empirical Formula: C9H17NO3
Molecular Weight: 187.24
MDL number: MFCD06656141
EINECS: 218-697-7
SAFETY DATA SHEET (SDS)
Update Date: 2023-10-18 10:44:45

What is 1-Boc-Azetidine-3-yl-methanol?

Description

1-Boc-Azetidine-3-yl-methanol is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). This compound is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.

Chemical properties

Clear colorless liquid

The Uses of 1-Boc-Azetidine-3-yl-methanol

It is an intermediate in organic syntheses

Properties of 1-Boc-Azetidine-3-yl-methanol

Melting point:	55 °C
Boiling point:	268-273℃
Density	1.115
Flash point:	117°(243°F)
storage temp.	2-8°C
solubility	Soluble in Dimethyl sulfoxide (DMSO).
form	powder to lump
pka	14.82±0.10(Predicted)
color	White to Almost white
InChI	InChI=1S/C9H17NO3/c1-9(2,3)13-8(12)10-4-7(5-10)6-11/h7,11H,4-6H2,1-3H3

Safety information for 1-Boc-Azetidine-3-yl-methanol

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up.