1-Boc-Azetidine-3-yl-methanol
- CAS NO.：142253-56-3
- Empirical Formula: C9H17NO3
- Molecular Weight: 187.24
- MDL number: MFCD06656141
- EINECS: 218-697-7
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-10-18 10:44:45
What is 1-Boc-Azetidine-3-yl-methanol?
Description
1-Boc-Azetidine-3-yl-methanol is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). This compound is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.
Chemical properties
Clear colorless liquid
The Uses of 1-Boc-Azetidine-3-yl-methanol
It is an intermediate in organic syntheses
Properties of 1-Boc-Azetidine-3-yl-methanol
| Melting point: | 55 °C |
| Boiling point: | 268-273℃ |
| Density | 1.115 |
| Flash point: | 117°(243°F) |
| storage temp. | 2-8°C |
| solubility | Soluble in Dimethyl sulfoxide (DMSO). |
| form | powder to lump |
| pka | 14.82±0.10(Predicted) |
| color | White to Almost white |
| InChI | InChI=1S/C9H17NO3/c1-9(2,3)13-8(12)10-4-7(5-10)6-11/h7,11H,4-6H2,1-3H3 |
Safety information for 1-Boc-Azetidine-3-yl-methanol
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up. |
Computed Descriptors for 1-Boc-Azetidine-3-yl-methanol
| InChIKey | HXRDRJKAEYHOBB-UHFFFAOYSA-N |
| SMILES | N1(C(OC(C)(C)C)=O)CC(CO)C1 |
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