1-Cbz-4-Piperidone

Synonym(s):1-(Benzyloxycarbonyl)-4-piperidinone;1-Cbz-4-Piperidone;Benzyl 4-oxo-1-piperidinecarboxylate

CAS NO.：19099-93-5
Empirical Formula: C13H15NO3
Molecular Weight: 233.26
MDL number: MFCD00673144
EINECS: 606-227-7
SAFETY DATA SHEET (SDS)
Update Date: 2024-05-30 19:23:35

What is 1-Cbz-4-Piperidone?

Chemical properties

Colourless Oil

The Uses of 1-Cbz-4-Piperidone

Protected piperidinone that can undergo interesting synthetic transformations including the Knoevenagel reaction,1 hetero-Diels-Alder reactions,2 and reactions to form N-(4-piperidinyl)oxindoles.3

General Description

1-Cbz-4-Piperidone is the starting material in biheteroaromatic diphosphine oxides-catalyzed stereoselective direct aldol condensation reactions.

Properties of 1-Cbz-4-Piperidone

Melting point:	38-41°C
Boiling point:	114-140 °C/0.25 mmHg (lit.)
Density	1.172 g/mL at 25 °C (lit.)
refractive index	n20/D 1.542(lit.)
Flash point:	>110 °C
storage temp.	Sealed in dry,2-8°C
solubility	Chloroform, Dichloromethane, Ethyl Acetate, Methanol
form	Solid or Lliquid
pka	-1.63±0.20(Predicted)
Specific Gravity	1.185
color	White to pale yellow
BRN	1533716
InChI	InChI=1S/C13H15NO3/c15-12-6-8-14(9-7-12)13(16)17-10-11-4-2-1-3-5-11/h1-5H,6-10H2
CAS DataBase Reference	19099-93-5(CAS DataBase Reference)

Safety information for 1-Cbz-4-Piperidone

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H412:Hazardous to the aquatic environment, long-term hazard
Precautionary Statement Codes	P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P273:Avoid release to the environment. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P501:Dispose of contents/container to..…