1-BENZOYL-3-PHENYL-2-THIOUREA

CAS NO.：4921-82-8
Empirical Formula: C14H12N2OS
Molecular Weight: 256.32
MDL number: MFCD00022118
SAFETY DATA SHEET (SDS)
Update Date: 2024-08-11 15:28:25

What is 1-BENZOYL-3-PHENYL-2-THIOUREA?

Description

TM-2-51 (4921-82-8) is a highly potent and isozyme selective activator of recombinant HDAC8. Increases the activity of HDAC8 by a factor of 12 at 10 μM. No activation of other HDACs is observed. TM-2-51 rescues the activity of catalytically compromised HDAC8 mutants?in vitro.2

References

1) Singh?et al. (2011), Histone deacetylase activators: N-acetylthioureas as highly potent and isozyme selective activators for human histone deacetylase-8 on a fluorescent substrate; Bioorg. Med. Chem. Lett.,?21?5920 2) Decross?et al. (2014), Compromised Structure and Function of HDAC8 Mutants Identified in Cornelia de Lange Syndrome Spectrum Disorders; ACS Chem. Biol.,?9?2157 3) Singh?et al. (2015),?Mechanism of N-acylthiourea Mediated Activation of Human Histone Deacetylase 8 (HDAC8) at Molecular and Cellular Levels; J. Biol. Chem.,?290?6607

Properties of 1-BENZOYL-3-PHENYL-2-THIOUREA

Melting point:	159 °C
Density	1.290±0.06 g/cm3(Predicted)
storage temp.	-20°
solubility	Soluble in DMSO (greater than 50 mg/ml) or in Ethanol (up to 8 mg/ml).
pka	9.49±0.70(Predicted)
form	solid
color	Off-white
Stability:	Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
CAS DataBase Reference	4921-82-8(CAS DataBase Reference)