1-BENZHYDRYLPIPERAZINE
Synonym(s):1-Benzhydrylpiperazine
- CAS NO.：841-77-0
- Empirical Formula: C17H20N2
- Molecular Weight: 252.35
- MDL number: MFCD00038379
- EINECS: 212-667-7
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-08-07 19:09:42
What is 1-BENZHYDRYLPIPERAZINE?
Chemical properties
white to light yellow crystalline powder
The Uses of 1-BENZHYDRYLPIPERAZINE
1-Benzhydrylpiperazine is an intermediate used in drug synthesis
The Uses of 1-BENZHYDRYLPIPERAZINE
Cinnarizine (C465300) impurity.
The Uses of 1-BENZHYDRYLPIPERAZINE
1-(Diphenylmethyl)piperazine [N-(Diphenylmethyl)piperazine] may be used for the synthesis of 2-nitro-3,4,4-trichloro-1-(propylthio)-1-[4-(diphenylmethyl)piperazin-1-yl]-1,3-butadiene and 2-nitro-3,4,4-trichloro-1-(octadecylthio)-1-[4-(diphenylmethyl)piperazin-1-yl]-1,3-butadiene.
What are the applications of Application
1-(Diphenylmethyl)piperazine is an intermediate for use in synthesis
Synthesis Reference(s)
Journal of the American Chemical Society, 77, p. 1098, 1955 DOI: 10.1021/ja01610a006
General Description
1-(Diphenylmethyl)piperazine is an intermediate during drug synthesis. It has been reported to be formed during the oxidative metabolism of cinnarizine (CZ) [1-(diphenylmethyl)-4-(3-phenyl-2-propenyl)-piperazine] in rat liver microsomes. It reacts with quinone in acetonitrile, followed by oxidation with an alkaline potassium ferricyanide, to afford 4-amino-3,6-di(tert-butyl)-o-benzoquinones.
Flammability and Explosibility
Not classified
Properties of 1-BENZHYDRYLPIPERAZINE
| Melting point: | 90-93 °C |
| Boiling point: | 185°C/2mmHg(lit.) |
| Density | 1.0546 (rough estimate) |
| vapor pressure | 0.001Pa at 20℃ |
| refractive index | 1.5794 (estimate) |
| Flash point: | 115 °C |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | Methanol (Slightly) |
| pka | 9.05±0.10(Predicted) |
| form | Crystalline Powder |
| color | White to light yellow |
| Water Solubility | 0.45 g/L (20 ºC) |
| Sensitive | Air Sensitive |
| BRN | 222773 |
| CAS DataBase Reference | 841-77-0(CAS DataBase Reference) |
| NIST Chemistry Reference | Benzhydryl piperazine(841-77-0) |
Safety information for 1-BENZHYDRYLPIPERAZINE
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H332:Acute toxicity,inhalation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P280:Wear protective gloves/protective clothing/eye protection/face protection. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up. P501:Dispose of contents/container to..… |
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