1-(5-Chloro-2-hydroxyphenyl)ethanone

CAS NO.：1450-74-4
Empirical Formula: C8H7ClO2
Molecular Weight: 170.59
MDL number: MFCD00067788
EINECS: 215-916-8
SAFETY DATA SHEET (SDS)
Update Date: 2024-07-02 08:55:06

What is 1-(5-Chloro-2-hydroxyphenyl)ethanone?

Chemical properties

slightly yellow crystalline powder or chunks

The Uses of 1-(5-Chloro-2-hydroxyphenyl)ethanone

5′-Chloro-2′-hydroxyacetophenone (5-chloro-2- hydroxyacetophenone) may be used in the synthesis of:

6-chloro-2-methyl-4H-chrome-4-one
1-(2-hydroxyphenyl)-5-phenyl-2,4-pentadien-1-ones
1-(2-hydroxyphenyl)-5-phenyl-2,4-pentadien-1-ones
2-styrenyl allyl ether

Preparation

Preparation by Fries rearrangement of 4-chlorophenyl acetate with aluminium chloride without solvent between 110° and 200°(90–100% yield).

General Description

5′-Chloro-2′-hydroxyacetophenone (5-chloro-2- hydroxyacetophenone) on condensation with salicylhydrazide yields Schiff base, which is reported to form copper(II) complexes. Dipole moment of 5-chloro-2- hydroxyacetophenone has been evaluated in benzene solution.

Properties of 1-(5-Chloro-2-hydroxyphenyl)ethanone

Melting point:	54-56 °C(lit.)
Boiling point:	126-128 °C28 mm Hg(lit.)
Density	1.2315 (rough estimate)
refractive index	1.5590 (estimate)
Flash point:	107-109°C/12mm
storage temp.	Sealed in dry,Room Temperature
pka	9.72±0.18(Predicted)
form	Solid
BRN	1365589
CAS DataBase Reference	1450-74-4(CAS DataBase Reference)
NIST Chemistry Reference	Ethanone, 1-(5-chloro-2-hydroxyphenyl)-(1450-74-4)

Safety information for 1-(5-Chloro-2-hydroxyphenyl)ethanone

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.