1-(5-Chloro-2-hydroxyphenyl)ethanone
- CAS NO.：1450-74-4
- Empirical Formula: C8H7ClO2
- Molecular Weight: 170.59
- MDL number: MFCD00067788
- EINECS: 215-916-8
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-07-02 08:55:06
What is 1-(5-Chloro-2-hydroxyphenyl)ethanone?
Chemical properties
slightly yellow crystalline powder or chunks
The Uses of 1-(5-Chloro-2-hydroxyphenyl)ethanone
5′-Chloro-2′-hydroxyacetophenone (5-chloro-2- hydroxyacetophenone) may be used in the synthesis of:
- 6-chloro-2-methyl-4H-chrome-4-one
- 1-(2-hydroxyphenyl)-5-phenyl-2,4-pentadien-1-ones
- 1-(2-hydroxyphenyl)-5-phenyl-2,4-pentadien-1-ones
- 2-styrenyl allyl ether
Preparation
Preparation by Fries rearrangement of 4-chlorophenyl acetate with aluminium chloride without solvent between 110° and 200°(90–100% yield).
General Description
5′-Chloro-2′-hydroxyacetophenone (5-chloro-2- hydroxyacetophenone) on condensation with salicylhydrazide yields Schiff base, which is reported to form copper(II) complexes. Dipole moment of 5-chloro-2- hydroxyacetophenone has been evaluated in benzene solution.
Properties of 1-(5-Chloro-2-hydroxyphenyl)ethanone
| Melting point: | 54-56 °C(lit.) |
| Boiling point: | 126-128 °C28 mm Hg(lit.) |
| Density | 1.2315 (rough estimate) |
| refractive index | 1.5590 (estimate) |
| Flash point: | 107-109°C/12mm |
| storage temp. | Sealed in dry,Room Temperature |
| pka | 9.72±0.18(Predicted) |
| form | Solid |
| BRN | 1365589 |
| CAS DataBase Reference | 1450-74-4(CAS DataBase Reference) |
| NIST Chemistry Reference | Ethanone, 1-(5-chloro-2-hydroxyphenyl)-(1450-74-4) |
Safety information for 1-(5-Chloro-2-hydroxyphenyl)ethanone
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 1-(5-Chloro-2-hydroxyphenyl)ethanone
| InChIKey | XTGCUDZCCIRWHL-UHFFFAOYSA-N |
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