1-(4,4-DIPHENYL-3-BUTENYL)-3-PIPERIDINECARBOXYLIC ACID HYDROCHLORIDE
Synonym(s):1-(4,4-Diphenyl-3-butenyl)-3-piperidinecarboxylic acid hydrochloride
- CAS NO.：85375-15-1
- Empirical Formula: C22H26ClNO2
- Molecular Weight: 371.9
- MDL number: MFCD01321071
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-09-04 15:51:00
What is 1-(4,4-DIPHENYL-3-BUTENYL)-3-PIPERIDINECARBOXYLIC ACID HYDROCHLORIDE?
The Uses of 1-(4,4-DIPHENYL-3-BUTENYL)-3-PIPERIDINECARBOXYLIC ACID HYDROCHLORIDE
SKF-89976A is a GABA transporters (GATs) type 1 inhibitor.
What are the applications of Application
SKF-89976A is a GABA transporter type 1 inhibitor
Biological Activity
A potent GABA uptake inhibitor, selective for GAT-1 (IC 50 values are 0.13, 550, 944 and 7210 μ M for hGAT-1, rGAT-2, hGAT-3 and hBGT-1 respectively). Inhibits transport current competitively (K i = 7 μ M) and transmitter-gated current non-competitively (K i = 0.03 nM). Able to pass the blood-brain barrier after systemic administration and is active in vivo .
storage
+4°C (desiccate)
Properties of 1-(4,4-DIPHENYL-3-BUTENYL)-3-PIPERIDINECARBOXYLIC ACID HYDROCHLORIDE
| storage temp. | Inert atmosphere,2-8°C |
| solubility | DMSO: 20 mg/mL, soluble |
| form | solid |
| color | white |
Safety information for 1-(4,4-DIPHENYL-3-BUTENYL)-3-PIPERIDINECARBOXYLIC ACID HYDROCHLORIDE
Computed Descriptors for 1-(4,4-DIPHENYL-3-BUTENYL)-3-PIPERIDINECARBOXYLIC ACID HYDROCHLORIDE
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