1-(4-CHLORO-2-HYDROXYPHENYL)PROPAN-1-ONE
- CAS NO.：1127-97-5
- Empirical Formula: C9H9ClO2
- Molecular Weight: 184.62
- MDL number: MFCD00218578
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-07-16 18:25:32
What is 1-(4-CHLORO-2-HYDROXYPHENYL)PROPAN-1-ONE?
Preparation
Preparation by Fries rearrangement of m-chlo- rophenyl propionate (b.p.0.8 90°) with aluminium chloride,
without solvent at 100° for 2 h (92%), at 140° for 2 h (89%), ? at 140–150° for 3 h, at 130° for 2 h (77%), at 165° for 1 h (72%), at 50° for 3 h (55%) or at 30–40° (53%)
n nitrobenzene at 25° for 6 h (87%)
Preparation by Fries rearrangement of m-chlorophenyl propionate with titanium tetrachloride at 100° for 2 h (75%)
Also obtained by Friedel–Crafts reaction of propionyl chloride with m-chlorophenol in the presence of aluminium chloride
Also obtained by isomerization of 2-chloro-4-hydroxypropiophenone on heating with aluminium chloride between 165° and 200° (30–70%).
Properties of 1-(4-CHLORO-2-HYDROXYPHENYL)PROPAN-1-ONE
| Melting point: | 49 °C |
Safety information for 1-(4-CHLORO-2-HYDROXYPHENYL)PROPAN-1-ONE
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 1-(4-CHLORO-2-HYDROXYPHENYL)PROPAN-1-ONE
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