1-(3,4-DICHLOROPHENYL)-3-DIMETHYLAMINO-1-PROPANONE HCL
- CAS NO.：75144-12-6
- Empirical Formula: C11H14Cl3NO
- Molecular Weight: 282.59
- MDL number: MFCD01220371
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-19 20:33:22
What is 1-(3,4-DICHLOROPHENYL)-3-DIMETHYLAMINO-1-PROPANONE HCL?
Biological Activity
Antitrypanosomal agent 1 is a potent and selective inhibitor of trypanothione reductase with IC50 of 3.3 μM. It inhibits glutathione reductase with IC50 of 64.8 μM; inhibits Trypanosoma brucei with EC50 of 1 μM. It has antitrypanosomal activity.
in vitro
Antitrypanosomal agent 1 (compound 8a) has an selectivity for TR (GR IC50/TR IC50) of 20.
Properties of 1-(3,4-DICHLOROPHENYL)-3-DIMETHYLAMINO-1-PROPANONE HCL
| Melting point: | 186 - 188°C |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| color | Off-White |
| Water Solubility | Water: 10 mg/mL (35.39 mM) |
Safety information for 1-(3,4-DICHLOROPHENYL)-3-DIMETHYLAMINO-1-PROPANONE HCL
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 1-(3,4-DICHLOROPHENYL)-3-DIMETHYLAMINO-1-PROPANONE HCL
New Products
4-AMINO-TETRAHYDRO-PYRAN-4-CARBOXYLIC ACID HCL 4-(Dimethylamino)tetrahydro-2H-pyran-4-carbonitrile 4-Aminotetrahydropyran-4-carbonitrile Hydrochloride (R)-3-Aminobutanenitrile Hydrochloride 3-((Dimethylamino)methyl)-5-methylhexan-2-one oxalate 1,4-Dioxa-8-azaspiro[4.5]decane 5-Bromo-2-nitropyridine Nimesulide BP Aceclofenac IP/BP/EP Diclofenac Sodium IP/BP/EP/USP Mefenamic Acid IP/BP/EP/USP Ornidazole IP Diclofenac Potassium THOMAIND PAPER PH 2.0 TO 4.5 1 BOX BUFFER CAPSULE PH 9.2 - 10 CAP SODIUM CHLORIDE 0.1N CVS ALLOXAN MONOHYDRATE 98% PLATINUM 0.5% ON 3 MM ALUMINA PELLETS (TYPE 73) LITHIUM AAS SOLUTION 2-Bromo-1-(bromomethyl)-3-chloro-5-nitrobenzene 2-Bromo-3-nitroaniline N-(3-Hydroxypropyl)-N-methylacetamide 3-Bromo-6-chloropyridazine 4-ethyl-3-nitrobenzoic acidRelated products of tetrahydrofuran
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