1-(3,4-DICHLOROBENZYL)-1H-INDOLE-2,3-DIONE
- CAS NO.:79183-19-0
- Empirical Formula: C15H9Cl2NO2
- Molecular Weight: 306.14
- MDL number: MFCD00141556
- EINECS: 200-256-5
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-19 20:33:22
What is 1-(3,4-DICHLOROBENZYL)-1H-INDOLE-2,3-DIONE?
The Uses of 1-(3,4-DICHLOROBENZYL)-1H-INDOLE-2,3-DIONE
Apoptosis Activator 2 activates caspases in a cytochrome c-dependent manner and induces apoptosis in tumor cells.
The Uses of 1-(3,4-DICHLOROBENZYL)-1H-INDOLE-2,3-DIONE
Activates apoptosis in cells; shows selectivity for cancer cells against normal cell lines
What are the applications of Application
Apoptosis Activator 2 is an indoledione caspase activator
Definition
ChEBI: 1-[(3,4-dichlorophenyl)methyl]indole-2,3-dione is a member of indoles.
Biological Activity
Apoptosis activator; promotes the cytochrome c-dependent oligomerization of Apaf-1 into the mature apoptosome. Increases procaspase-9 processing and subsequent caspase-3 activation. Induces apoptosis in tumor cells (IC 50 = 4-9 μ M for leukaemia cells) with weak or no effect on normal cell lines or those defective/deficient in Apaf-1, caspase-9 or caspase-3 activity (IC 50 > 40 μ M).
storage
Room temperature
References
[1] nguyen jt, wells ja. direct activation of the apoptosis machinery as a mechanism to target cancer cells. proc natl acad sci u s a. 2003 jun 24;100(13):7533-8.
[2] nguyen tv, jayaraman a, quaglino a, pike cj. androgens selectively protect against apoptosis in hippocampal neurones. j neuroendocrinol. 2010 sep;22(9):1013-22.
Properties of 1-(3,4-DICHLOROBENZYL)-1H-INDOLE-2,3-DIONE
Boiling point: | 470.6±55.0 °C(Predicted) |
Density | 1.494 |
Flash point: | 238.4℃ |
storage temp. | Keep in dark place,Sealed in dry,2-8°C |
solubility | Soluble in DMSO |
pka | -2.69±0.20(Predicted) |
form | Orange to red solid. |
color | Yellow to orange |
Sensitive | Light Sensitive |
Safety information for 1-(3,4-DICHLOROBENZYL)-1H-INDOLE-2,3-DIONE
Computed Descriptors for 1-(3,4-DICHLOROBENZYL)-1H-INDOLE-2,3-DIONE
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