Contact us: +91 9550333722 040 - 40102781
Structured search
India
Choose your country
Different countries will display different contents
Try our best to find the right business for you.
My chemicalbook

Welcome back!

HomeProduct name list1-(3,4-DICHLOROBENZYL)-1H-INDOLE-2,3-DIONE

1-(3,4-DICHLOROBENZYL)-1H-INDOLE-2,3-DIONE

  • CAS NO.:79183-19-0
  • Empirical Formula: C15H9Cl2NO2
  • Molecular Weight: 306.14
  • MDL number: MFCD00141556
  • EINECS: 200-256-5
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-10-30 18:52:02
1-(3,4-DICHLOROBENZYL)-1H-INDOLE-2,3-DIONE Structural

What is 1-(3,4-DICHLOROBENZYL)-1H-INDOLE-2,3-DIONE?

The Uses of 1-(3,4-DICHLOROBENZYL)-1H-INDOLE-2,3-DIONE

Apoptosis Activator 2 activates caspases in a cytochrome c-dependent manner and induces apoptosis in tumor cells.

The Uses of 1-(3,4-DICHLOROBENZYL)-1H-INDOLE-2,3-DIONE

Activates apoptosis in cells; shows selectivity for cancer cells against normal cell lines

What are the applications of Application

Apoptosis Activator 2 is an indoledione caspase activator

Definition

ChEBI: 1-[(3,4-dichlorophenyl)methyl]indole-2,3-dione is a member of indoles.

Biological Activity

Apoptosis activator; promotes the cytochrome c-dependent oligomerization of Apaf-1 into the mature apoptosome. Increases procaspase-9 processing and subsequent caspase-3 activation. Induces apoptosis in tumor cells (IC 50 = 4-9 μ M for leukaemia cells) with weak or no effect on normal cell lines or those defective/deficient in Apaf-1, caspase-9 or caspase-3 activity (IC 50 > 40 μ M).

storage

Room temperature

References

[1] nguyen jt, wells ja. direct activation of the apoptosis machinery as a mechanism to target cancer cells. proc natl acad sci u s a. 2003 jun 24;100(13):7533-8.
[2] nguyen tv, jayaraman a, quaglino a, pike cj. androgens selectively protect against apoptosis in hippocampal neurones. j neuroendocrinol. 2010 sep;22(9):1013-22.

Properties of 1-(3,4-DICHLOROBENZYL)-1H-INDOLE-2,3-DIONE

Boiling point: 470.6±55.0 °C(Predicted)
Density  1.494
Flash point: 238.4℃
storage temp.  Keep in dark place,Sealed in dry,2-8°C
solubility  Soluble in DMSO
pka -2.69±0.20(Predicted)
form  Orange to red solid.
color  Yellow to orange
Sensitive  Light Sensitive

Safety information for 1-(3,4-DICHLOROBENZYL)-1H-INDOLE-2,3-DIONE

Computed Descriptors for 1-(3,4-DICHLOROBENZYL)-1H-INDOLE-2,3-DIONE

Related products of tetrahydrofuran

You may like

Statement: All products displayed on this website are only used for non medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.