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HomeProduct name list1-(3,4-DICHLOROBENZYL)-1H-INDOLE-2,3-DIONE

1-(3,4-DICHLOROBENZYL)-1H-INDOLE-2,3-DIONE

  • CAS NO.:79183-19-0
  • Empirical Formula: C15H9Cl2NO2
  • Molecular Weight: 306.14
  • MDL number: MFCD00141556
  • EINECS: 200-256-5
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-19 20:33:22
1-(3,4-DICHLOROBENZYL)-1H-INDOLE-2,3-DIONE Structural

What is 1-(3,4-DICHLOROBENZYL)-1H-INDOLE-2,3-DIONE?

The Uses of 1-(3,4-DICHLOROBENZYL)-1H-INDOLE-2,3-DIONE

Apoptosis Activator 2 activates caspases in a cytochrome c-dependent manner and induces apoptosis in tumor cells.

The Uses of 1-(3,4-DICHLOROBENZYL)-1H-INDOLE-2,3-DIONE

Activates apoptosis in cells; shows selectivity for cancer cells against normal cell lines

What are the applications of Application

Apoptosis Activator 2 is an indoledione caspase activator

Definition

ChEBI: 1-[(3,4-dichlorophenyl)methyl]indole-2,3-dione is a member of indoles.

Biological Activity

Apoptosis activator; promotes the cytochrome c-dependent oligomerization of Apaf-1 into the mature apoptosome. Increases procaspase-9 processing and subsequent caspase-3 activation. Induces apoptosis in tumor cells (IC 50 = 4-9 μ M for leukaemia cells) with weak or no effect on normal cell lines or those defective/deficient in Apaf-1, caspase-9 or caspase-3 activity (IC 50 > 40 μ M).

storage

Room temperature

References

[1] nguyen jt, wells ja. direct activation of the apoptosis machinery as a mechanism to target cancer cells. proc natl acad sci u s a. 2003 jun 24;100(13):7533-8.
[2] nguyen tv, jayaraman a, quaglino a, pike cj. androgens selectively protect against apoptosis in hippocampal neurones. j neuroendocrinol. 2010 sep;22(9):1013-22.

Properties of 1-(3,4-DICHLOROBENZYL)-1H-INDOLE-2,3-DIONE

Boiling point: 470.6±55.0 °C(Predicted)
Density  1.494
Flash point: 238.4℃
storage temp.  Keep in dark place,Sealed in dry,2-8°C
solubility  Soluble in DMSO
pka -2.69±0.20(Predicted)
form  Orange to red solid.
color  Yellow to orange
Sensitive  Light Sensitive

Safety information for 1-(3,4-DICHLOROBENZYL)-1H-INDOLE-2,3-DIONE

Computed Descriptors for 1-(3,4-DICHLOROBENZYL)-1H-INDOLE-2,3-DIONE

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