γ-Secretase Inhibitor XXI

Synonym(s):γ-Secretase Inhibitor XXI, Compound E - CAS 209986-17-4 - Calbiochem;(S,S)- 2-[2-(3,5-Difluorophenyl)-acetylamino]-N-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-propionamide, Compound E;StemSelect Compound E - CAS 209986-17-4 - Calbiochem

CAS NO.：209986-17-4
Empirical Formula: C27H24F2N4O3
Molecular Weight: 490.5
SAFETY DATA SHEET (SDS)
Update Date: 2024-11-12 15:22:20

What is γ-Secretase Inhibitor XXI?

The Uses of γ-Secretase Inhibitor XXI

A cell-permeable, potent, selective, peptidomimetic, non-transition-state analog inhibitor of -secretase and Notch processing

What are the applications of Application

Compound E is a cell permeable non-competitive γ-secretase inhibitor that regulates signaling pathways.

Definition

ChEBI: Compound E is an L-alanine derivative that is the amide obtained by formal condensation of the carboxy group of N-[(3,5-difluorophenyl)acetyl]-L-alanine with the amino group of (3S)-3-amino-1-methyl-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one. An inhibitor of memapsin 2 (gamma-secretase). It has a role as an EC 3.4.23.46 (memapsin 2) inhibitor. It is a 1,4-benzodiazepinone, a L-alanine derivative and a difluorobenzene.

storage

+4°C

Properties of γ-Secretase Inhibitor XXI

Boiling point:	778.6±60.0 °C(Predicted)
Density	1.31
storage temp.	= -70C
solubility	Soluble in DMSO
form	Liquid
pka	12.54±0.40(Predicted)
color	White to off-white
Sensitive	Light Sensitive

Safety information for γ-Secretase Inhibitor XXI

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.