(+)-PINORESINOL
- CAS NO.:487-36-5
- Empirical Formula: C20H22O6
- Molecular Weight: 358.39
- MDL number: MFCD07784516
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-05 08:26:49
What is (+)-PINORESINOL?
Description
(+)-Pinoresinol is a lignan that has been found in Forsythia and virgin olive oils and has diverse biological activities, including antioxidant, anticancer, and anti-inflammatory properties. It is an inhibitor of α-glucosidase and maltase (IC50s = 492 and 34.3 μM in Baker’s yeast and rat small intestine, respectively). (+)-Pinoresinol scavenges ABTS , but not 2,2-diphenyl-1-picrylhydrazyl (DPPH; ), radicals in cell-free assays (IC50s = 13.43 and >200 μg/ml, respectively). It is cytotoxic to A549, HepG2, and MCF-7, but not U251 and Bcap-37, cells with IC50 values of 29.35, 62.35, 75.32, >80, and >80 μM, respectively. (+)-Pinoresinol prevents cell death induced by glutamate in HT22 cells (EC50 = 6.96 μM) and inhibits LPS-induced nitric oxide production in RAW 264.7 cells (IC50 = 7.89 μM).
The Uses of (+)-PINORESINOL
(+)-Pinoresinol is a lignan found in olive oil and in other plants. This phenolic compound was reported to have antioxidant and anticancer potential.
Definition
ChEBI: An enantiomer of pinoresinol having (+)-1S,3aR,4S,6aR-configuration.
Properties of (+)-PINORESINOL
Melting point: | 112 °C |
Boiling point: | 556.5±50.0 °C(Predicted) |
Density | 1.385 g/cm3 |
storage temp. | Sealed in dry,Room Temperature |
solubility | DMSO: ≥6mg/mL |
form | Solid |
pka | 9.54±0.35(Predicted) |
color | white to tan |
Safety information for (+)-PINORESINOL
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for (+)-PINORESINOL
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