(+)-MENTHOL
Synonym(s):(+)-Menthol;(1S,2R,5S)-2-Isopropyl-5-methylcyclohexanol
- CAS NO.:15356-60-2
- Empirical Formula: C10H20O
- Molecular Weight: 156.27
- MDL number: MFCD00062983
- EINECS: 239-387-8
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-19 20:33:22
What is (+)-MENTHOL?
Description
(+)-Menthol is a monoterpene alcohol that has been found in Cannabis and has antifungal activity. It inhibits the growth of F. verticillioides (MIC = 1.5 mM). Unlike (–)-menthol, (+)-menthol does not exhibit analgesia, antibacterial, anticancer, or cholinesterase inhibitory activities.
Chemical properties
(+)-MENTHOL is white low melting solid
The Uses of (+)-MENTHOL
(1S,2R,5S)-(+)-menthol can undergo acylation with acid anhydrides in the presence of trimethylsilyl trifluoromethanesulfonate to form the corresponding acylated products.
The Uses of (+)-MENTHOL
(+)-MENTHOL is used for oral gel patch or film containing herb extracts or Chinese medicine, fruit extract, spearmint, and menthol for smoking cessation.
Definition
ChEBI: (+)-menthol is a p-menthan-3-ol which has (1S,2R,5S)-stereochemistry. In contrast to (-)-menthol, the (+)-enantiomer occurs only rarely in nature. It is an enantiomer of a (-)-menthol.
General Description
(1S,2R,5S)-(+)-menthol is a chiral secondary alcohol. Its alcohol group can be protected as 2-tetrahydrofuranyl ether by reacting with bromotrichloromethane and tetrahydrofuran.
Synthesis
Prod.: by Meerwein-Ponndorf-Verley reduction of l-Menthone, resuhing in approximately two-thirds d-Neomenthol plus one-third i-Menthol. It can also be produced by reduction of d-Menthone.
Properties of (+)-MENTHOL
Melting point: | 43-44 °C (lit.) |
Boiling point: | 103-104 °C/9 mmHg (lit.) |
Density | 0.890 |
vapor pressure | 0.8 mm Hg ( 20 °C) |
refractive index | 50 ° (C=10, EtOH) |
Flash point: | 196 °F |
storage temp. | 2-8°C |
solubility | Chloroform (Slightly), Methanol (Slightly) |
form | Solid |
pka | 15.30±0.60(Predicted) |
color | Colourless to Off-White Oil to Low-Melting |
Odor | mentholic |
optical activity | [α]23/D +48°, c = 10 in ethanol |
Water Solubility | Soluble in methanol (almost transparency), chloroform, alcohols, water (456 mg/L at 25°C), and ether. |
BRN | 1902292 |
Dielectric constant | 3.2(Ambient) |
CAS DataBase Reference | 15356-60-2(CAS DataBase Reference) |
EPA Substance Registry System | Cyclohexanol, 5-methyl-2-(1-methylethyl)-, (1S,2R,5S)- (15356-60-2) |
Safety information for (+)-MENTHOL
Signal word | Danger |
Pictogram(s) |
Corrosion Corrosives GHS05 Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H315:Skin corrosion/irritation H318:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for (+)-MENTHOL
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