(+/-)-DOI HYDROCHLORIDE (+-)-2,5-DIMETHO XY-4-
Synonym(s):(±)-1-(2,5-Dimethoxy-4-iodophenyl)-2-aminopropane hydrochloride;(±)-2,5-Dimethoxy-4-iodoamphetamine hydrochloride;(±)-DOI
- CAS NO.:42203-78-1
- Empirical Formula: C11H16INO2.ClH
- Molecular Weight: 357.613
- MDL number: MFCD00055199
- EINECS: 636-989-6
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-10-07 17:44:49
What is (+/-)-DOI HYDROCHLORIDE (+-)-2,5-DIMETHO XY-4-?
The Uses of (+/-)-DOI HYDROCHLORIDE (+-)-2,5-DIMETHO XY-4-
Hydrochloride (cas# 42203-78-1) is a useful research chemical.??DOI Hydrochloride is a 5-??HT2A??/2C agonist that stimulates hypothalamic neurons to increase the secretion of several hormones
General Description
A Certified Spiking Solution? suited for GC/MS or LC/MS phenethylamine testing applications in forensic analysis, clinical toxicology, or urine drug testing. DOI is a D-substituted amphetamine in the phenethylamine family of hallucinogenic drugs. This designer drug is an extremely potent psychedelic with a long duration of action.
Biological Activity
Brain penetrant, mixed 5-HT 2A /5-HT 2C receptor agonist (K i values are 0.7, 2.4 and 20 nM for 5-HT 2A , 5-HT 2C and 5-HT 2B receptors respectively). Reduces rapid eye movement (REM) and slow wave sleep and increases waking in the rat. Hallucinogenic agent. Acts via 5-HT 2A receptors to inhibit the inflammatory effects of tumor necrosis factor (TNF)- α .
Biochem/physiol Actions
(±)-DOI hydrochloride is a potent and selective 5-HT2 serotonin receptor agonist that crosses the blood-brain barrier, increases dopamine turnover and the treatment with DOI counteracted the expression of the nicotine-induced locomotor and neurochemical sensitization, but had no effect on nicotine-induced behavioral disinhibition. The responses to DOI provide evidence that of these receptors are abundant in the cortex, and show relatively lower levels in hippocampus and cerebellum.
storage
Store at RT
Properties of (+/-)-DOI HYDROCHLORIDE (+-)-2,5-DIMETHO XY-4-
Flash point: | 9℃ |
storage temp. | Store at RT |
solubility | H2O: soluble10mg/mL |
form | solid |
color | white to off-white |
Water Solubility | Soluble to 50 mM in water |
Safety information for (+/-)-DOI HYDROCHLORIDE (+-)-2,5-DIMETHO XY-4-
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for (+/-)-DOI HYDROCHLORIDE (+-)-2,5-DIMETHO XY-4-
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