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HomeProduct name list(+/-)-DOI HYDROCHLORIDE (+-)-2,5-DIMETHO XY-4-

(+/-)-DOI HYDROCHLORIDE (+-)-2,5-DIMETHO XY-4-

Synonym(s):(±)-1-(2,5-Dimethoxy-4-iodophenyl)-2-aminopropane hydrochloride;(±)-2,5-Dimethoxy-4-iodoamphetamine hydrochloride;(±)-DOI

  • CAS NO.:42203-78-1
  • Empirical Formula: C11H16INO2.ClH
  • Molecular Weight: 357.613
  • MDL number: MFCD00055199
  • EINECS: 636-989-6
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2023-10-07 17:44:49
(+/-)-DOI HYDROCHLORIDE (+-)-2,5-DIMETHO XY-4- Structural

What is (+/-)-DOI HYDROCHLORIDE (+-)-2,5-DIMETHO XY-4-?

The Uses of (+/-)-DOI HYDROCHLORIDE (+-)-2,5-DIMETHO XY-4-

Hydrochloride (cas# 42203-78-1) is a useful research chemical.??DOI Hydrochloride is a 5-??HT2A??/2C agonist that stimulates hypothalamic neurons to increase the secretion of several hormones

General Description

A Certified Spiking Solution? suited for GC/MS or LC/MS phenethylamine testing applications in forensic analysis, clinical toxicology, or urine drug testing. DOI is a D-substituted amphetamine in the phenethylamine family of hallucinogenic drugs. This designer drug is an extremely potent psychedelic with a long duration of action.

Biological Activity

Brain penetrant, mixed 5-HT 2A /5-HT 2C receptor agonist (K i values are 0.7, 2.4 and 20 nM for 5-HT 2A , 5-HT 2C and 5-HT 2B receptors respectively). Reduces rapid eye movement (REM) and slow wave sleep and increases waking in the rat. Hallucinogenic agent. Acts via 5-HT 2A receptors to inhibit the inflammatory effects of tumor necrosis factor (TNF)- α .

Biochem/physiol Actions

(±)-DOI hydrochloride is a potent and selective 5-HT2 serotonin receptor agonist that crosses the blood-brain barrier, increases dopamine turnover and the treatment with DOI counteracted the expression of the nicotine-induced locomotor and neurochemical sensitization, but had no effect on nicotine-induced behavioral disinhibition. The responses to DOI provide evidence that of these receptors are abundant in the cortex, and show relatively lower levels in hippocampus and cerebellum.

storage

Store at RT

Properties of (+/-)-DOI HYDROCHLORIDE (+-)-2,5-DIMETHO XY-4-

Flash point: 9℃
storage temp.  Store at RT
solubility  H2O: soluble10mg/mL
form  solid
color  white to off-white
Water Solubility  Soluble to 50 mM in water

Safety information for (+/-)-DOI HYDROCHLORIDE (+-)-2,5-DIMETHO XY-4-

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P264:Wash hands thoroughly after handling.
P264:Wash skin thouroughly after handling.
P271:Use only outdoors or in a well-ventilated area.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352:IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for (+/-)-DOI HYDROCHLORIDE (+-)-2,5-DIMETHO XY-4-

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