(-)-BETA-HYDRASTINE
Synonym(s):(1R,9S)-(−)-β-Hydrastine
- CAS NO.:118-08-1
- Empirical Formula: C21H21NO6
- Molecular Weight: 383.39
- MDL number: MFCD00152561
- EINECS: 204-233-0
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-05 19:05:58
What is (-)-BETA-HYDRASTINE?
Description
(1R,9S)-(–)-β-Hydrastine is an enantiomer of the alkaloid hydrastine that inhibits dopamine biosynthesis (IC50 = 20.7 μM in PC12 cells) by inhibiting tyrosine hydroxylase activity. It inhibits dopamine release with an IC50 value of 66.5 μM in the presence of high extracellular K+ levels. It also inhibits L-type and caffeine-activated store-operated Ca2+ channels and prevents Ca2+ leakage from intracellular stores.
The Uses of (-)-BETA-HYDRASTINE
anesthetic (local), antiarrhythmic
The Uses of (-)-BETA-HYDRASTINE
(-)-β-Hydrastine is an inhibitor of Dopamine biosynthesis.
What are the applications of Application
(1R,9S)-(–)-β-Hydrastine is an inhibitor of Dopamine biosynthesis
Definition
ChEBI: A natural product found in Hydrastis canadensis.
Properties of (-)-BETA-HYDRASTINE
Melting point: | 132℃ |
Boiling point: | 510.32°C (rough estimate) |
alpha | D20 -50° (c = 0.3 in abs alc) |
Density | 1.339±0.06 g/cm3 (20 ºC 760 Torr) |
refractive index | 1.5614 (estimate) |
storage temp. | −20°C |
solubility | DMF: 10 mg/ml; DMSO: 10 mg/ml |
form | A crystalline solid |
pka | 7.8(at 25℃) |
color | White to light yellow |
Water Solubility | 30mg/L(20 ºC) |
CAS DataBase Reference | 118-08-1(CAS DataBase Reference) |
Safety information for (-)-BETA-HYDRASTINE
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H302:Acute toxicity,oral |
Computed Descriptors for (-)-BETA-HYDRASTINE
Related products of tetrahydrofuran
Centella asiatica whole plant
daurisoline
Xanthiside
2-[2-(Methylamino)benzoyl]-3,4-dihydro-β-carboline-1(2H)-one
veratramine
VERATRINE
VERATRIDINE
menisdaurin
You may like
-
Hydrastine CAS 118-08-1View Details
118-08-1 -
77-92-9 99%View Details
77-92-9 -
77-92-9 99%View Details
77-92-9 -
8000-27-9 CEDAR WOOD OIL 99%View Details
8000-27-9 -
AMMONIUM DICHROMATE 7789-09-5 99%View Details
7789-09-5 -
77-78-1 DIMETHYL SULPHATE 99%View Details
77-78-1 -
7778-80-5 POTASSIUM SULPHATE 99%View Details
7778-80-5 -
95-54-5 99%View Details
95-54-5
Statement: All products displayed on this website are only used for non medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.