(-)-BETA-HYDRASTINE
Synonym(s):(1R,9S)-(−)-β-Hydrastine
- CAS NO.：118-08-1
- Empirical Formula: C21H21NO6
- Molecular Weight: 383.39
- MDL number: MFCD00152561
- EINECS: 204-233-0
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-19 23:02:33
What is (-)-BETA-HYDRASTINE?
Description
(1R,9S)-(–)-β-Hydrastine is an enantiomer of the alkaloid hydrastine that inhibits dopamine biosynthesis (IC50 = 20.7 μM in PC12 cells) by inhibiting tyrosine hydroxylase activity. It inhibits dopamine release with an IC50 value of 66.5 μM in the presence of high extracellular K+ levels. It also inhibits L-type and caffeine-activated store-operated Ca2+ channels and prevents Ca2+ leakage from intracellular stores.
The Uses of (-)-BETA-HYDRASTINE
anesthetic (local), antiarrhythmic
The Uses of (-)-BETA-HYDRASTINE
(-)-β-Hydrastine is an inhibitor of Dopamine biosynthesis.
What are the applications of Application
(1R,9S)-(–)-β-Hydrastine is an inhibitor of Dopamine biosynthesis
Definition
ChEBI: A natural product found in Hydrastis canadensis.
Properties of (-)-BETA-HYDRASTINE
| Melting point: | 132℃ |
| Boiling point: | 510.32°C (rough estimate) |
| alpha | D20 -50° (c = 0.3 in abs alc) |
| Density | 1.339±0.06 g/cm3 (20 ºC 760 Torr) |
| refractive index | 1.5614 (estimate) |
| storage temp. | −20°C |
| solubility | DMF: 10 mg/ml; DMSO: 10 mg/ml |
| form | A crystalline solid |
| pka | 7.8(at 25℃) |
| color | White to light yellow |
| Water Solubility | 30mg/L(20 ºC) |
| CAS DataBase Reference | 118-08-1(CAS DataBase Reference) |
Safety information for (-)-BETA-HYDRASTINE
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral |
Computed Descriptors for (-)-BETA-HYDRASTINE
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