(+)-ALPHA-DIHYDROTETRABENAZINE
- CAS NO.：3466-75-9
- Empirical Formula: C19H29NO3
- Molecular Weight: 319.44
- MDL number: MFCD20275194
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-08-01 17:24:36
What is (+)-ALPHA-DIHYDROTETRABENAZINE?
Description
Dihydrotetrabenazine is an active metabolite of the vesicular monoamine transporter 2 (VMAT2) inhibitor tetrabenazine that is generated by hepatic carbonyl reductases. Dihydrotetrabenazine binds to mouse pons medulla, hypothalamus, and striatum (Kds = 2.72, 2.28, and 2.4 nM, respectively) and inhibits synaptic vesicular serotonin (5-HT) uptake (IC50s = 2.2, 2.8, and 2.3 nM, respectively). It also binds to human caudate nucleus, hippocampus, and substantia nigra pars compacta (Kds = 2.9, 2.5, and 2.8 nM, respectively). Dihydrotetrabenazine stereoisomers bind to VMAT2 in rat striatum.
Chemical properties
Colourless solid
Definition
ChEBI: B-Dihydrotetrabenazine is a member of isoquinolines.
Properties of (+)-ALPHA-DIHYDROTETRABENAZINE
| Boiling point: | 457.8±45.0 °C(Predicted) |
| Density | 1.13±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | Chloroform: soluble; Methanol: soluble |
| form | A solid |
| pka | 14.75±0.40(Predicted) |
| CAS DataBase Reference | 3466-75-9 |
Safety information for (+)-ALPHA-DIHYDROTETRABENAZINE
Computed Descriptors for (+)-ALPHA-DIHYDROTETRABENAZINE
(+)-ALPHA-DIHYDROTETRABENAZINE manufacturer
LOBERAN PHARMA
1Y
Phone:+91-8006595568
Whatsapp: +91- 8006595568
product: 3466-75-9 9,10-dimethoxy-3-(propan-2-yl)-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-ol >99%
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