(+/-)-6-CHLORO-7,8-DIHYDROXY-3-ALLYL-1-PHENYL-2,3,4,5-TETRAHYDRO-1H-3-BENZAZEPINE HYDROBROMIDE
Synonym(s):(±)-6-Chloro-7,8-dihydroxy-3-allyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrobromide;(±)-SKF-82958 hydrobromide;6-Chloro-N-allyl-SKF-38393 hydrobromide
- CAS NO.：80751-65-1
- Empirical Formula: C19H20ClNO2
- Molecular Weight: 329.82
- MDL number: MFCD00069235
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-10-28 23:16:16
What is (+/-)-6-CHLORO-7,8-DIHYDROXY-3-ALLYL-1-PHENYL-2,3,4,5-TETRAHYDRO-1H-3-BENZAZEPINE HYDROBROMIDE?
The Uses of (+/-)-6-CHLORO-7,8-DIHYDROXY-3-ALLYL-1-PHENYL-2,3,4,5-TETRAHYDRO-1H-3-BENZAZEPINE HYDROBROMIDE
Chloro-APB hydrobromide has been used to pharmacologically stimulate D1 dopamine receptors and study its influence on locomotor response in fat mass and obesity-associated protein (FTO) deficient dopamine D1 receptor-expressing medium spiny neurons (D1 MSNs) of mice.
What are the applications of Application
Chloro-APB hydrobromide is a full D1 dopamine receptor agonist
Definition
ChEBI: 9-chloro-5-phenyl-3-prop-2-enyl-1,2,4,5-tetrahydro-3-benzazepine-7,8-diol is a benzazepine.
Biochem/physiol Actions
Chloro-APB hydrobromide, also known as SKF 82958, is a D1 dopamine receptor agonist. D1 receptor agonists prevent and reverse fentanyl-induced respiratory depression, without impairing opioid analgesia, in cats.
Properties of (+/-)-6-CHLORO-7,8-DIHYDROXY-3-ALLYL-1-PHENYL-2,3,4,5-TETRAHYDRO-1H-3-BENZAZEPINE HYDROBROMIDE
| Boiling point: | 473.7±45.0 °C(Predicted) |
| Density | 1.234±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | H2O: 3.7 mg/mL |
| form | solid |
| pka | 8.73±0.40(Predicted) |
| color | tan |
Safety information for (+/-)-6-CHLORO-7,8-DIHYDROXY-3-ALLYL-1-PHENYL-2,3,4,5-TETRAHYDRO-1H-3-BENZAZEPINE HYDROBROMIDE
Computed Descriptors for (+/-)-6-CHLORO-7,8-DIHYDROXY-3-ALLYL-1-PHENYL-2,3,4,5-TETRAHYDRO-1H-3-BENZAZEPINE HYDROBROMIDE
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