(+)-3-(3,4-dimethoxyphenyl)-6-[(5,6-dimethoxyphenethyl)methylamino]hexane-3-carbonitrile
- CAS NO.：38321-02-7
- Empirical Formula: C27H38N2O4
- Molecular Weight: 454.61
- MDL number: MFCD00864679
- EINECS: 253-878-4
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-07-08 08:28:38
![(+)-3-(3,4-dimethoxyphenyl)-6-[(5,6-dimethoxyphenethyl)methylamino]hexane-3-carbonitrile Structural](https://img.chemicalbook.in/CAS/GIF/38321-02-7.gif)
What is (+)-3-(3,4-dimethoxyphenyl)-6-[(5,6-dimethoxyphenethyl)methylamino]hexane-3-carbonitrile?
Chemical properties
Off-White Solid
The Uses of (+)-3-(3,4-dimethoxyphenyl)-6-[(5,6-dimethoxyphenethyl)methylamino]hexane-3-carbonitrile
Both isomers inhibit the p-glycoprotein efflux pump in multidrug resistant tumor cells
What are the applications of Application
(R)-(+)-Verapamil Hydrochloride is an inhibitor of p-glycoprotein efflux pump
Definition
ChEBI: A 2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile that has R configuration. It competitively inhibits the multidrug resistance efflux pump P-glycoprotein (MDR-1, EC 3.6.3.44), thereby p tentially increasing the effectiveness of a wide range of antineoplastic drugs which are inactivated by MDR-1 mechanisms. Dexverapamil exhibits lower calcium antagonistic activity and toxicity than racemic verapamil.
Properties of (+)-3-(3,4-dimethoxyphenyl)-6-[(5,6-dimethoxyphenethyl)methylamino]hexane-3-carbonitrile
| Melting point: | 129-131°C |
| Boiling point: | 586.1±50.0 °C(Predicted) |
| Density | 1.058±0.06 g/cm3(Predicted) |
| pka | 8.97±0.50(Predicted) |
Safety information for (+)-3-(3,4-dimethoxyphenyl)-6-[(5,6-dimethoxyphenethyl)methylamino]hexane-3-carbonitrile
Computed Descriptors for (+)-3-(3,4-dimethoxyphenyl)-6-[(5,6-dimethoxyphenethyl)methylamino]hexane-3-carbonitrile
New Products
Tubulysin E (R)-tert-butyl (4-methyl-1-oxopentan-3-yl)carbamate Tubulysin I (2S,4R)-4-amino-2-methyl-5-phenylpentanoic acid hydrochloride 2H-Pyran, 4-ethynyltetrahydro- 3-METHYLAZETIDIN-3-OL HYDROCHLORIDE 2-(azetidin-3-ylidene)acetonitrile (hydrochloride) Methyl (R)-1-Boc-4,4-difluoropyrrolidine-2-carboxylate 2,2-Difluoropropanol Isoxazole, 3-[[[5-(difluoromethoxy)-1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]methyl]thio]-4,5-dihydro-5,5-dimethyl- 2-[[(3aR,4S,6R,6aS)-6-Aminotetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]ethanol ethanedioate Imeglimin Hydrochloride IH 2-(1-(Mercaptomethyl) cyclopropyl) acetonitrile (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine 2-[2-[3(S)-3[2-(7-chloro-2-quinolinyl) ethenyl] phenyl-3- hydroxyl propyl] phenyl]-2-propanol Fuel shell Latanoprostene Bunod Lubiprostone Magnesium Trisilicate Flame Retardant Zinc Borate methyl 3-fluoro-4- thiomorpholino phenylcarbamate (R)-(3-(3-fluoro-4- thiomorpholinophenyl)-2- oxooxazolidin-4-yl) methyl methanesulfonate 1H-Imidazole-4-carbonitrile 7-Methoxyquinoline-4-carboxylic acidRelated products of tetrahydrofuran
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